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Fabrication and evaluation of conductive elastomer electrodes for neural stimulation.

Publication ,  Journal Article
Keohan, F; Wei, XF; Wongsarnpigoon, A; Lazaro, E; Darga, JE; Grill, WM
Published in: Journal of biomaterials science. Polymer edition
January 2007

This study explored the feasibility of applying nanocomposites derived from conducting organic polymers and silicone elastomers to fabricate electrodes for neural stimulation. A novel combination of nanoparticulate polypyrrole polymerized within a processable elastomeric silicone host polymer was evaluated in vitro and in vivo. The electrical properties of the elastomeric conductors were strongly dependent on their composition, and mixtures were identified that provided high and stable conductivity. Methods were developed for incorporating conductive polymer-siloxane co-polymer nanocomposite and silicone insulating polymers into thin-layered structures for simple single-poled electrode fabrication. In vitro testing revealed that the materials were stable under continuous pulsing for at least 10 days. Single contact prototype nerve cuff electrodes were fabricated and device functionality was demonstrated in vivo following acute implantation. The results of this study demonstrate the feasibility of conductive elastomers for peripheral nerve stimulating electrodes. Matching the mechanical properties of cuff electrode to those of the underlying neural tissue is expected to improve the long-term tissue response to the presence of the electrode.

Duke Scholars

Published In

Journal of biomaterials science. Polymer edition

DOI

EISSN

1568-5624

ISSN

0920-5063

Publication Date

January 2007

Volume

18

Issue

8

Start / End Page

1057 / 1073

Related Subject Headings

  • Siloxanes
  • Silicones
  • Neurons
  • Nerve Tissue
  • Nanoparticles
  • Nanocomposites
  • Electrodes, Implanted
  • Electrodes
  • Electric Conductivity
  • Elastomers
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Keohan, F., Wei, X. F., Wongsarnpigoon, A., Lazaro, E., Darga, J. E., & Grill, W. M. (2007). Fabrication and evaluation of conductive elastomer electrodes for neural stimulation. Journal of Biomaterials Science. Polymer Edition, 18(8), 1057–1073. https://doi.org/10.1163/156856207781494395
Keohan, Frank, Xuefeng F. Wei, Amorn Wongsarnpigoon, Edgar Lazaro, John E. Darga, and Warren M. Grill. “Fabrication and evaluation of conductive elastomer electrodes for neural stimulation.Journal of Biomaterials Science. Polymer Edition 18, no. 8 (January 2007): 1057–73. https://doi.org/10.1163/156856207781494395.
Keohan F, Wei XF, Wongsarnpigoon A, Lazaro E, Darga JE, Grill WM. Fabrication and evaluation of conductive elastomer electrodes for neural stimulation. Journal of biomaterials science Polymer edition. 2007 Jan;18(8):1057–73.
Keohan, Frank, et al. “Fabrication and evaluation of conductive elastomer electrodes for neural stimulation.Journal of Biomaterials Science. Polymer Edition, vol. 18, no. 8, Jan. 2007, pp. 1057–73. Epmc, doi:10.1163/156856207781494395.
Keohan F, Wei XF, Wongsarnpigoon A, Lazaro E, Darga JE, Grill WM. Fabrication and evaluation of conductive elastomer electrodes for neural stimulation. Journal of biomaterials science Polymer edition. 2007 Jan;18(8):1057–1073.

Published In

Journal of biomaterials science. Polymer edition

DOI

EISSN

1568-5624

ISSN

0920-5063

Publication Date

January 2007

Volume

18

Issue

8

Start / End Page

1057 / 1073

Related Subject Headings

  • Siloxanes
  • Silicones
  • Neurons
  • Nerve Tissue
  • Nanoparticles
  • Nanocomposites
  • Electrodes, Implanted
  • Electrodes
  • Electric Conductivity
  • Elastomers