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A method to estimate the spatial extent of activation in thalamic deep brain stimulation.

Publication ,  Journal Article
Kuncel, AM; Cooper, SE; Grill, WM
Published in: Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
September 2008

The goal of this study was to develop, evaluate, and apply a method to quantify the unknown spatial extent of activation in deep brain stimulation (DBS) of the ventral intermedius nucleus (Vim) of the thalamus.The amplitude-distance relationship and the threshold amplitudes to elicit clinical responses were combined to estimate the unknown amplitude-distance constant and the distance between the electrode and the border between the Vim and the ventrocaudal nucleus (Vc) of the thalamus. We tested the sensitivity of the method to errors in the input parameters, and subsequently applied the method to estimate the amplitude-distance constant from clinically-measured threshold amplitudes.The method enabled estimation of the amplitude-distance constant with a median squared error of 0.07-0.23V/mm2 and provided an estimate of the distance between the electrode and the Vc/Vim border with a median squared error of 0.01-0.04mm. Application of the method to clinically-measured threshold amplitudes to elicit paresthesias estimated the amplitude-distance constant to be 0.22V/mm2.The method enabled robust quantification of the spatial extent of activation in thalamic DBS and predicted that stimulation amplitudes of 1-3.5V would produce a mean effective radius of activation of 2.0-3.9mm.Knowing the spatial extent of activation may improve methods of electrode placement and stimulation parameter selection in DBS.

Duke Scholars

Published In

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology

DOI

EISSN

1872-8952

ISSN

1388-2457

Publication Date

September 2008

Volume

119

Issue

9

Start / End Page

2148 / 2158

Related Subject Headings

  • Thalamus
  • Neurology & Neurosurgery
  • Models, Biological
  • Humans
  • Functional Laterality
  • Evaluation Studies as Topic
  • Electrodes
  • Dose-Response Relationship, Radiation
  • Differential Threshold
  • Deep Brain Stimulation
 

Citation

APA
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ICMJE
MLA
NLM
Kuncel, A. M., Cooper, S. E., & Grill, W. M. (2008). A method to estimate the spatial extent of activation in thalamic deep brain stimulation. Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology, 119(9), 2148–2158. https://doi.org/10.1016/j.clinph.2008.02.025
Kuncel, Alexis M., Scott E. Cooper, and Warren M. Grill. “A method to estimate the spatial extent of activation in thalamic deep brain stimulation.Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology 119, no. 9 (September 2008): 2148–58. https://doi.org/10.1016/j.clinph.2008.02.025.
Kuncel AM, Cooper SE, Grill WM. A method to estimate the spatial extent of activation in thalamic deep brain stimulation. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. 2008 Sep;119(9):2148–58.
Kuncel, Alexis M., et al. “A method to estimate the spatial extent of activation in thalamic deep brain stimulation.Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology, vol. 119, no. 9, Sept. 2008, pp. 2148–58. Epmc, doi:10.1016/j.clinph.2008.02.025.
Kuncel AM, Cooper SE, Grill WM. A method to estimate the spatial extent of activation in thalamic deep brain stimulation. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. 2008 Sep;119(9):2148–2158.
Journal cover image

Published In

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology

DOI

EISSN

1872-8952

ISSN

1388-2457

Publication Date

September 2008

Volume

119

Issue

9

Start / End Page

2148 / 2158

Related Subject Headings

  • Thalamus
  • Neurology & Neurosurgery
  • Models, Biological
  • Humans
  • Functional Laterality
  • Evaluation Studies as Topic
  • Electrodes
  • Dose-Response Relationship, Radiation
  • Differential Threshold
  • Deep Brain Stimulation