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Utility of hyperbaric oxygen in treatment of bisphosphonate-related osteonecrosis of the jaws.

Publication ,  Journal Article
Freiberger, JJ
Published in: J Oral Maxillofac Surg
May 2009

Bisphosphonates suppress bone turnover by disrupting osteoclast signal transduction, maturation, and longevity. In some patients, it has been hypothesized that suppressed turnover can impair oral wound healing, leading to a distressing, osteopetrosis-like jaw necrosis called bisphosphonate-related osteonecrosis of the jaws (BRONJ). Hyperbaric oxygen (HBO), as an adjunct to surgery and antibiotics, might have utility in the treatment of BRONJ because it produces reactive oxygen and nitrogen species that positively modulate the redox-sensitive intracellular signaling molecules involved in bone turnover. The efficacy of HBO in the treatment of BRONJ is currently under investigation in randomized controlled trials at Duke University and the University of Minnesota, and the early results have been encouraging. This report discusses osteoclast biology, how HBO has the potential to augment bone turnover by way of the signaling effects on osteoclasts, the available clinical data on HBO in the treatment of BRONJ, the ongoing randomized controlled trials of HBO, and the study-associated efforts to find biomarkers to characterize an individual's risk of developing this disease.

Duke Scholars

Published In

J Oral Maxillofac Surg

DOI

EISSN

1531-5053

Publication Date

May 2009

Volume

67

Issue

5 Suppl

Start / End Page

96 / 106

Location

United States

Related Subject Headings

  • Signal Transduction
  • Randomized Controlled Trials as Topic
  • Oxygen
  • Osteonecrosis
  • Osteoclasts
  • Jaw Diseases
  • Hyperbaric Oxygenation
  • Humans
  • Growth Substances
  • Diphosphonates
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Freiberger, J. J. (2009). Utility of hyperbaric oxygen in treatment of bisphosphonate-related osteonecrosis of the jaws. J Oral Maxillofac Surg, 67(5 Suppl), 96–106. https://doi.org/10.1016/j.joms.2008.12.003
Freiberger, John J. “Utility of hyperbaric oxygen in treatment of bisphosphonate-related osteonecrosis of the jaws.J Oral Maxillofac Surg 67, no. 5 Suppl (May 2009): 96–106. https://doi.org/10.1016/j.joms.2008.12.003.
Freiberger JJ. Utility of hyperbaric oxygen in treatment of bisphosphonate-related osteonecrosis of the jaws. J Oral Maxillofac Surg. 2009 May;67(5 Suppl):96–106.
Freiberger, John J. “Utility of hyperbaric oxygen in treatment of bisphosphonate-related osteonecrosis of the jaws.J Oral Maxillofac Surg, vol. 67, no. 5 Suppl, May 2009, pp. 96–106. Pubmed, doi:10.1016/j.joms.2008.12.003.
Freiberger JJ. Utility of hyperbaric oxygen in treatment of bisphosphonate-related osteonecrosis of the jaws. J Oral Maxillofac Surg. 2009 May;67(5 Suppl):96–106.
Journal cover image

Published In

J Oral Maxillofac Surg

DOI

EISSN

1531-5053

Publication Date

May 2009

Volume

67

Issue

5 Suppl

Start / End Page

96 / 106

Location

United States

Related Subject Headings

  • Signal Transduction
  • Randomized Controlled Trials as Topic
  • Oxygen
  • Osteonecrosis
  • Osteoclasts
  • Jaw Diseases
  • Hyperbaric Oxygenation
  • Humans
  • Growth Substances
  • Diphosphonates