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Clinical response and outcome of infection with Salmonella enterica serotype Typhi with decreased susceptibility to fluoroquinolones: a United States foodnet multicenter retrospective cohort study.

Publication ,  Journal Article
Crump, JA; Kretsinger, K; Gay, K; Hoekstra, RM; Vugia, DJ; Hurd, S; Segler, SD; Megginson, M; Luedeman, LJ; Shiferaw, B; Hanna, SS; Joyce, KW ...
Published in: Antimicrob Agents Chemother
April 2008

Patients with typhoid fever due to Salmonella enterica serotype Typhi strains for which fluoroquinolones MICs are elevated yet that are classified as susceptible by the current interpretive criteria of the Clinical and Laboratory Standards Institute may not respond adequately to fluoroquinolone therapy. Patients from seven U.S. states with invasive Salmonella serotype Typhi infection between 1999 and 2002 were enrolled in a multicenter retrospective cohort study. Patients infected with Salmonella serotype Typhi isolates with ciprofloxacin MICs of 0.12 to 1 microg/ml (decreased ciprofloxacin susceptibility but not resistant to ciprofloxacin [DCS]) were compared with patients infected with isolates with ciprofloxacin MICs <0.12 microg/ml for fever clearance time and treatment failure. Of 71 patients, 30 (43%) were female and 24 (34%) were infected with Salmonella serotype Typhi with DCS; the median age was 14 years (range, 1 to 51 years). Twenty-one (88%) of 24 isolates with DCS were resistant to nalidixic acid. The median antimicrobial-related fever clearance times in the DCS and non-DCS groups were 92 h (range, 21 to 373 h) and 72 h (range, 19 to 264 h) (P = 0.010), respectively, and the fluoroquinolone-related fever clearance times in the DCS and non-DCS groups were 90 h (range, 9 to 373 h) and 64 h (range, 34 to 204 h) (P = 0.153), respectively. Four (17%) of 24 patients in the DCS group and 2 (4%) of 46 patients in the non-DCS group (relative risk, 2.5; 95% confidence interval, 1.2 to 5.1) experienced treatment failure. Associations persisted after adjustment for potential confounders. We demonstrate that patients infected with Salmonella serotype Typhi isolates with DCS show evidence of a longer time to fever clearance and more frequent treatment failure. Nalidixic acid screening does not detect all isolates with DCS.

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Published In

Antimicrob Agents Chemother

DOI

ISSN

0066-4804

Publication Date

April 2008

Volume

52

Issue

4

Start / End Page

1278 / 1284

Location

United States

Related Subject Headings

  • United States
  • Typhoid Fever
  • Treatment Outcome
  • Salmonella typhi
  • Retrospective Studies
  • Population Surveillance
  • Middle Aged
  • Microbiology
  • Microbial Sensitivity Tests
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
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Crump, J. A., Kretsinger, K., Gay, K., Hoekstra, R. M., Vugia, D. J., Hurd, S., … Emerging Infections Program FoodNet and NARMS Working Groups. (2008). Clinical response and outcome of infection with Salmonella enterica serotype Typhi with decreased susceptibility to fluoroquinolones: a United States foodnet multicenter retrospective cohort study. Antimicrob Agents Chemother, 52(4), 1278–1284. https://doi.org/10.1128/AAC.01509-07
Crump, John A., Katrina Kretsinger, Kathryn Gay, R Michael Hoekstra, Duc J. Vugia, Sharon Hurd, Susan D. Segler, et al. “Clinical response and outcome of infection with Salmonella enterica serotype Typhi with decreased susceptibility to fluoroquinolones: a United States foodnet multicenter retrospective cohort study.Antimicrob Agents Chemother 52, no. 4 (April 2008): 1278–84. https://doi.org/10.1128/AAC.01509-07.
Crump, John A., et al. “Clinical response and outcome of infection with Salmonella enterica serotype Typhi with decreased susceptibility to fluoroquinolones: a United States foodnet multicenter retrospective cohort study.Antimicrob Agents Chemother, vol. 52, no. 4, Apr. 2008, pp. 1278–84. Pubmed, doi:10.1128/AAC.01509-07.
Crump JA, Kretsinger K, Gay K, Hoekstra RM, Vugia DJ, Hurd S, Segler SD, Megginson M, Luedeman LJ, Shiferaw B, Hanna SS, Joyce KW, Mintz ED, Angulo FJ, Emerging Infections Program FoodNet and NARMS Working Groups. Clinical response and outcome of infection with Salmonella enterica serotype Typhi with decreased susceptibility to fluoroquinolones: a United States foodnet multicenter retrospective cohort study. Antimicrob Agents Chemother. 2008 Apr;52(4):1278–1284.

Published In

Antimicrob Agents Chemother

DOI

ISSN

0066-4804

Publication Date

April 2008

Volume

52

Issue

4

Start / End Page

1278 / 1284

Location

United States

Related Subject Headings

  • United States
  • Typhoid Fever
  • Treatment Outcome
  • Salmonella typhi
  • Retrospective Studies
  • Population Surveillance
  • Middle Aged
  • Microbiology
  • Microbial Sensitivity Tests
  • Male