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A cost-minimization analysis comparing azithromycin-based and levofloxacin-based protocols for the treatment of patients hospitalized with community-acquired pneumonia: results from the CAP-IN trial.

Publication ,  Journal Article
Samsa, GP; Matchar, DB; Harnett, J; Wilson, J
Published in: Chest
November 2005

BACKGROUND: A randomized trial was performed comparing azithromycin and levofloxacin for treating moderately to severely ill patients hospitalized with community-acquired pneumonia. This is a cost-minimization analysis comparing those regimens. METHODS: The cost-minimization analysis compares 81 patients receiving sequential therapy with IV azithromycin plus IV ceftriaxone followed by oral azithromycin with 82 patients receiving IV levofloxacin followed by oral levofloxacin, all with complete economic data over approximately 30 days, including information about hospitalization, study medications, home care, postdischarge utilization, and lost productivity. Units of utilization were multiplied by unit prices in order to estimate cost per patient. These total costs were compared using a two-sample t test. RESULTS: Direct medical costs of the azithromycin group were 2,481 US dollars less than the corresponding costs in the levofloxacin group (p = 0.03; 95% confidence interval, 238 US dollars to 4,724 US dollars). Most of the cost difference (2,300 US dollars) is attributable to hospital days, with the majority of these days being spent on the general medicine wards. The precise magnitude of the cost advantage attributable to azithromycin, if any, depends on both the reduction in length of hospital stay and its associated daily cost. CONCLUSIONS: Azithromycin was no more costly than levofloxacin, and perhaps less so. Cost is but one of many factors that should be considered by clinicians in decisions involving any individual patient.

Duke Scholars

Published In

Chest

DOI

ISSN

0012-3692

Publication Date

November 2005

Volume

128

Issue

5

Start / End Page

3246 / 3254

Location

United States

Related Subject Headings

  • United States
  • Respiratory System
  • Pneumonia, Bacterial
  • Ofloxacin
  • Male
  • Levofloxacin
  • Length of Stay
  • Humans
  • Hospitalization
  • Home Care Services
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Samsa, G. P., Matchar, D. B., Harnett, J., & Wilson, J. (2005). A cost-minimization analysis comparing azithromycin-based and levofloxacin-based protocols for the treatment of patients hospitalized with community-acquired pneumonia: results from the CAP-IN trial. Chest, 128(5), 3246–3254. https://doi.org/10.1378/chest.128.5.3246
Samsa, Gregory P., David B. Matchar, James Harnett, and Jerome Wilson. “A cost-minimization analysis comparing azithromycin-based and levofloxacin-based protocols for the treatment of patients hospitalized with community-acquired pneumonia: results from the CAP-IN trial.Chest 128, no. 5 (November 2005): 3246–54. https://doi.org/10.1378/chest.128.5.3246.
Journal cover image

Published In

Chest

DOI

ISSN

0012-3692

Publication Date

November 2005

Volume

128

Issue

5

Start / End Page

3246 / 3254

Location

United States

Related Subject Headings

  • United States
  • Respiratory System
  • Pneumonia, Bacterial
  • Ofloxacin
  • Male
  • Levofloxacin
  • Length of Stay
  • Humans
  • Hospitalization
  • Home Care Services