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Aclacinomycin A in the treatment of experimental proliferative vitreoretinopathy. Efficacy and toxicity in the rabbit eye.

Publication ,  Journal Article
Steinhorst, UH; Chen, EP; Hatchell, DL; Samsa, GP; Saloupis, PT; Westendorf, J; Machemer, R
Published in: Invest Ophthalmol Vis Sci
April 1993

PURPOSE: Aclacinomycin A is an oligosaccharide anthracycline that, by contrast with daunomycin, lacks carcinogenicity. The authors evaluated the efficacy of aclacinomycin A in prevention of experimental proliferative vitreoretinopathy (PVR) and its toxicity on the rabbit retina. METHODS: Dutch-belted rabbit were used to create a model for traction retinal detachment. Seven to 10 days after vitreous gas compression, 25,000 homologous fibroblasts were injected into the vitreous cavity. Subsequently, the eyes received either sham injections or doses of 6, 30, or 60 nmol of aclacinomycin A, respectively. The fundus findings were documented on days 7, 14, and 28 after the fibroblast injection. The toxicity studies were conducted according to the same protocol as was used for the efficacy evaluation but without the fibroblast injection. Simultaneous electroretinograms were recorded on days 0, 3, 7, and 14 from the right eyes that were injected with 30 or 60 nmol of aclacinomycin A and the left eyes that were sham injected. Morphologic studies were conducted on the eyes enucleated on days 3, 7, and 14 after drug exposure. RESULTS: Intraocular administration of 30 nmol of aclacinomycin A on day 2 after fibroblast injection resulted in a detachment rate of 37.5% (controls, 100%; P < 0.01, by Fisher's exact test). Administration of 60 nmol of aclacinomycin A 3 days after fibroblast injection resulted in a detachment rate of 26.7% (controls, 100%; P < 0.0001). Six nanomoles of aclacinomycin A 3 days after fibroblast injection had no effect. No electroretinogram changes were present in eyes treated with 30 nmol of aclacinomycin A. Such recordings from eyes exposed to 60 nmol of aclacinomycin A demonstrated decreased a- and b-waves on day 3; these completely recovered by day 7. Morphologic studies of these eyes revealed no damage to the retina. CONCLUSIONS: These results suggest that aclacinomycin A should be considered an alternative to daunomycin for treatment of human PVR because, in addition to its lack of carcinogenicity, it shows good efficacy and causes less retinal toxicity.

Duke Scholars

Published In

Invest Ophthalmol Vis Sci

ISSN

0146-0404

Publication Date

April 1993

Volume

34

Issue

5

Start / End Page

1753 / 1760

Location

United States

Related Subject Headings

  • Vitreous Body
  • Retinal Diseases
  • Retinal Detachment
  • Retina
  • Rabbits
  • Ophthalmology & Optometry
  • Male
  • Fundus Oculi
  • Follow-Up Studies
  • Fibroblasts
 

Citation

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MLA
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Steinhorst, U. H., Chen, E. P., Hatchell, D. L., Samsa, G. P., Saloupis, P. T., Westendorf, J., & Machemer, R. (1993). Aclacinomycin A in the treatment of experimental proliferative vitreoretinopathy. Efficacy and toxicity in the rabbit eye. Invest Ophthalmol Vis Sci, 34(5), 1753–1760.
Steinhorst, U. H., E. P. Chen, D. L. Hatchell, G. P. Samsa, P. T. Saloupis, J. Westendorf, and R. Machemer. “Aclacinomycin A in the treatment of experimental proliferative vitreoretinopathy. Efficacy and toxicity in the rabbit eye.Invest Ophthalmol Vis Sci 34, no. 5 (April 1993): 1753–60.
Steinhorst UH, Chen EP, Hatchell DL, Samsa GP, Saloupis PT, Westendorf J, et al. Aclacinomycin A in the treatment of experimental proliferative vitreoretinopathy. Efficacy and toxicity in the rabbit eye. Invest Ophthalmol Vis Sci. 1993 Apr;34(5):1753–60.
Steinhorst, U. H., et al. “Aclacinomycin A in the treatment of experimental proliferative vitreoretinopathy. Efficacy and toxicity in the rabbit eye.Invest Ophthalmol Vis Sci, vol. 34, no. 5, Apr. 1993, pp. 1753–60.
Steinhorst UH, Chen EP, Hatchell DL, Samsa GP, Saloupis PT, Westendorf J, Machemer R. Aclacinomycin A in the treatment of experimental proliferative vitreoretinopathy. Efficacy and toxicity in the rabbit eye. Invest Ophthalmol Vis Sci. 1993 Apr;34(5):1753–1760.

Published In

Invest Ophthalmol Vis Sci

ISSN

0146-0404

Publication Date

April 1993

Volume

34

Issue

5

Start / End Page

1753 / 1760

Location

United States

Related Subject Headings

  • Vitreous Body
  • Retinal Diseases
  • Retinal Detachment
  • Retina
  • Rabbits
  • Ophthalmology & Optometry
  • Male
  • Fundus Oculi
  • Follow-Up Studies
  • Fibroblasts