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Determination of quality of life-related utilities for health states relevant to ovarian cancer diagnosis and treatment.

Publication ,  Journal Article
Havrilesky, LJ; Broadwater, G; Davis, DM; Nolte, KC; Barnett, JC; Myers, ER; Kulasingam, S
Published in: Gynecol Oncol
May 2009

OBJECTIVES: (1) To define a set of health state descriptions related to screening, diagnosis, prognosis, and toxicities relevant to ovarian cancer; (2) To derive a set of quality of life-related utilities to be used for cost-effectiveness analyses. METHODS: A comprehensive list of health states was developed to represent the experiences of diagnostic testing for ovarian cancer, natural history of ovarian cancer (e.g., newly diagnosed early stage ovarian cancer, recurrent progressive ovarian cancer) and the most common chemotherapy-related toxicities (e.g. alopecia, peripheral neuropathy, pain, neutropenia, fatigue). Valuation of each health state was obtained through individual interviews of 13 ovarian cancer patients and 37 female members of the general public. Interviews employed visual analog score (VAS) and time trade off (TTO) methods of health state valuation. RESULTS: Mean TTO-derived utilities were higher than VAS-derived utilities by 0.118 U (p<0.0001). Mean VAS-derived utilities for screening tests were 0.83 and 0.81 for true negative blood test and ultrasound; 0.79 and 0.78 for false negative blood test and ultrasound, respectively. Patients and volunteers generally agreed in their preference ranking of chemotherapy-associated states, with lowest rankings being given to febrile neutropenia, grades 3-4 fatigue, and grades 3-4 nausea/vomiting. For 55% of chemotherapy-associated health states, the average utility assigned was higher for patients than for volunteers. CONCLUSIONS: This study establishes societal preferences for a number of health states related to screening, diagnosis and treatment of ovarian cancer that can be used for assessing the cost-effectiveness of different ovarian cancer screening and treatment regimens.

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Published In

Gynecol Oncol

DOI

EISSN

1095-6859

Publication Date

May 2009

Volume

113

Issue

2

Start / End Page

216 / 220

Location

United States

Related Subject Headings

  • Severity of Illness Index
  • Quality of Life
  • Ovarian Neoplasms
  • Oncology & Carcinogenesis
  • Neoplasm Recurrence, Local
  • Middle Aged
  • Humans
  • Health Status
  • Focus Groups
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
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Havrilesky, L. J., Broadwater, G., Davis, D. M., Nolte, K. C., Barnett, J. C., Myers, E. R., & Kulasingam, S. (2009). Determination of quality of life-related utilities for health states relevant to ovarian cancer diagnosis and treatment. Gynecol Oncol, 113(2), 216–220. https://doi.org/10.1016/j.ygyno.2008.12.026
Havrilesky, Laura J., Gloria Broadwater, Debra M. Davis, Kimberly C. Nolte, J Cory Barnett, Evan R. Myers, and Shalini Kulasingam. “Determination of quality of life-related utilities for health states relevant to ovarian cancer diagnosis and treatment.Gynecol Oncol 113, no. 2 (May 2009): 216–20. https://doi.org/10.1016/j.ygyno.2008.12.026.
Havrilesky LJ, Broadwater G, Davis DM, Nolte KC, Barnett JC, Myers ER, et al. Determination of quality of life-related utilities for health states relevant to ovarian cancer diagnosis and treatment. Gynecol Oncol. 2009 May;113(2):216–20.
Havrilesky, Laura J., et al. “Determination of quality of life-related utilities for health states relevant to ovarian cancer diagnosis and treatment.Gynecol Oncol, vol. 113, no. 2, May 2009, pp. 216–20. Pubmed, doi:10.1016/j.ygyno.2008.12.026.
Havrilesky LJ, Broadwater G, Davis DM, Nolte KC, Barnett JC, Myers ER, Kulasingam S. Determination of quality of life-related utilities for health states relevant to ovarian cancer diagnosis and treatment. Gynecol Oncol. 2009 May;113(2):216–220.
Journal cover image

Published In

Gynecol Oncol

DOI

EISSN

1095-6859

Publication Date

May 2009

Volume

113

Issue

2

Start / End Page

216 / 220

Location

United States

Related Subject Headings

  • Severity of Illness Index
  • Quality of Life
  • Ovarian Neoplasms
  • Oncology & Carcinogenesis
  • Neoplasm Recurrence, Local
  • Middle Aged
  • Humans
  • Health Status
  • Focus Groups
  • Female