Skip to main content
Journal cover image

Effects of cardiovascular medications on rate of functional decline in Alzheimer disease.

Publication ,  Journal Article
Rosenberg, PB; Mielke, MM; Tschanz, J; Cook, L; Corcoran, C; Hayden, KM; Norton, M; Rabins, PV; Green, RC; Welsh-Bohmer, KA; Breitner, JCS ...
Published in: Am J Geriatr Psychiatry
November 2008

BACKGROUND: Evidence suggests that cardiovascular medications, including statins and antihypertensive medications, may delay cognitive decline in patients with Alzheimer dementia (AD). We examined the association of cardiovascular medication use and rate of functional decline in a population-based cohort of individuals with incident AD. METHODS: In the Dementia Progression Study of the Cache County Study on Memory, Health, and Aging, 216 individuals with incident AD were identified and followed longitudinally with in-home visits for a mean of 3.0 years and 2.1 follow-up visits. The Clinical Dementia Rating (CDR) was completed at each follow-up. Medication use was inventoried during in-home visits. Generalized least-squares random-effects regression was performed with CDR Sum of Boxes (CDR-Sum) as the outcome and cardiovascular medication use as the major predictors. RESULTS: CDR-Sum increased an average of 1.69 points annually, indicating a steady decline in functioning. After adjustment for demographic variables and the baseline presence of cardiovascular conditions, use of statins (p = 0.03) and beta-blockers (p = 0.04) was associated with a slower annual rate of increase in CDR-Sum (slower rate of functional decline) of 0.75 and 0.68 points respectively, while diuretic use was associated with a faster rate of increase in CDR-Sum (p = 0.01; 0.96 points annually). Use of calcium-channel blockers, angiotensin-converting enzyme inhibitors, digoxin, or nitrates did not affect the rate of functional decline. CONCLUSIONS: In this population-based study of individuals with incident AD, use of statins and beta-blockers was associated with delay of functional decline. Further studies are needed to confirm these results and to determine whether treatment with these medications may help delay AD progression.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Am J Geriatr Psychiatry

DOI

EISSN

1545-7214

Publication Date

November 2008

Volume

16

Issue

11

Start / End Page

883 / 892

Location

England

Related Subject Headings

  • Severity of Illness Index
  • Risk Factors
  • Reproducibility of Results
  • Psychiatric Status Rating Scales
  • Neuropsychological Tests
  • Multivariate Analysis
  • Male
  • Longitudinal Studies
  • Linear Models
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Rosenberg, P. B., Mielke, M. M., Tschanz, J., Cook, L., Corcoran, C., Hayden, K. M., … Lyketsos, C. G. (2008). Effects of cardiovascular medications on rate of functional decline in Alzheimer disease. Am J Geriatr Psychiatry, 16(11), 883–892. https://doi.org/10.1097/JGP.0b013e318181276a
Rosenberg, P. B., M. M. Mielke, J. Tschanz, L. Cook, Chris Corcoran, K. M. Hayden, M. Norton, et al. “Effects of cardiovascular medications on rate of functional decline in Alzheimer disease.Am J Geriatr Psychiatry 16, no. 11 (November 2008): 883–92. https://doi.org/10.1097/JGP.0b013e318181276a.
Rosenberg PB, Mielke MM, Tschanz J, Cook L, Corcoran C, Hayden KM, et al. Effects of cardiovascular medications on rate of functional decline in Alzheimer disease. Am J Geriatr Psychiatry. 2008 Nov;16(11):883–92.
Rosenberg, P. B., et al. “Effects of cardiovascular medications on rate of functional decline in Alzheimer disease.Am J Geriatr Psychiatry, vol. 16, no. 11, Nov. 2008, pp. 883–92. Pubmed, doi:10.1097/JGP.0b013e318181276a.
Rosenberg PB, Mielke MM, Tschanz J, Cook L, Corcoran C, Hayden KM, Norton M, Rabins PV, Green RC, Welsh-Bohmer KA, Breitner JCS, Munger R, Lyketsos CG. Effects of cardiovascular medications on rate of functional decline in Alzheimer disease. Am J Geriatr Psychiatry. 2008 Nov;16(11):883–892.
Journal cover image

Published In

Am J Geriatr Psychiatry

DOI

EISSN

1545-7214

Publication Date

November 2008

Volume

16

Issue

11

Start / End Page

883 / 892

Location

England

Related Subject Headings

  • Severity of Illness Index
  • Risk Factors
  • Reproducibility of Results
  • Psychiatric Status Rating Scales
  • Neuropsychological Tests
  • Multivariate Analysis
  • Male
  • Longitudinal Studies
  • Linear Models
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors