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Better cognitive performance in elderly taking antioxidant vitamins E and C supplements in combination with nonsteroidal anti-inflammatory drugs: the Cache County Study.

Publication ,  Journal Article
Fotuhi, M; Zandi, PP; Hayden, KM; Khachaturian, AS; Szekely, CA; Wengreen, H; Munger, RG; Norton, MC; Tschanz, JT; Lyketsos, CG; Breitner, JCS ...
Published in: Alzheimers Dement
May 2008

Studies have shown less cognitive decline and lower risk of Alzheimer's disease in elderly individuals consuming either antioxidant vitamins or nonsteroidal anti-inflammatory drugs (NSAIDs). The potential of added benefit from their combined use has not been studied. We therefore analyzed data from 3,376 elderly participants of the Cache County Study who were given the Modified Mini-Mental State examination up to three times during a period of 8 years. Those who used a combination of vitamins E and C supplements and NSAIDs at baseline declined by an average 0.96 fewer points every 3 years than nonusers (P < .05). This apparent effect was attributable entirely to participants with the APOE epsilon4 allele, whose users declined by 2.25 fewer points than nonusers every 3 years (P < .05). These results suggest that among elderly individuals with an APOE epsilon4 allele, there is an association between using antioxidant supplements in combination with NSAIDs and less cognitive decline over time.

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Published In

Alzheimers Dement

DOI

EISSN

1552-5279

Publication Date

May 2008

Volume

4

Issue

3

Start / End Page

223 / 227

Location

United States

Related Subject Headings

  • Vitamin E
  • Neuropsychological Tests
  • Male
  • Humans
  • Geriatrics
  • Female
  • Drug Therapy, Combination
  • Dietary Supplements
  • Cognition
  • Brain
 

Citation

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Chicago
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MLA
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Fotuhi, M., Zandi, P. P., Hayden, K. M., Khachaturian, A. S., Szekely, C. A., Wengreen, H., … Welsh-Bohmer, K. (2008). Better cognitive performance in elderly taking antioxidant vitamins E and C supplements in combination with nonsteroidal anti-inflammatory drugs: the Cache County Study. Alzheimers Dement, 4(3), 223–227. https://doi.org/10.1016/j.jalz.2008.01.004
Fotuhi, Majid, Peter P. Zandi, Kathleen M. Hayden, Ara S. Khachaturian, Christine A. Szekely, Heidi Wengreen, Ronald G. Munger, et al. “Better cognitive performance in elderly taking antioxidant vitamins E and C supplements in combination with nonsteroidal anti-inflammatory drugs: the Cache County Study.Alzheimers Dement 4, no. 3 (May 2008): 223–27. https://doi.org/10.1016/j.jalz.2008.01.004.
Fotuhi M, Zandi PP, Hayden KM, Khachaturian AS, Szekely CA, Wengreen H, et al. Better cognitive performance in elderly taking antioxidant vitamins E and C supplements in combination with nonsteroidal anti-inflammatory drugs: the Cache County Study. Alzheimers Dement. 2008 May;4(3):223–7.
Fotuhi, Majid, et al. “Better cognitive performance in elderly taking antioxidant vitamins E and C supplements in combination with nonsteroidal anti-inflammatory drugs: the Cache County Study.Alzheimers Dement, vol. 4, no. 3, May 2008, pp. 223–27. Pubmed, doi:10.1016/j.jalz.2008.01.004.
Fotuhi M, Zandi PP, Hayden KM, Khachaturian AS, Szekely CA, Wengreen H, Munger RG, Norton MC, Tschanz JT, Lyketsos CG, Breitner JCS, Welsh-Bohmer K. Better cognitive performance in elderly taking antioxidant vitamins E and C supplements in combination with nonsteroidal anti-inflammatory drugs: the Cache County Study. Alzheimers Dement. 2008 May;4(3):223–227.
Journal cover image

Published In

Alzheimers Dement

DOI

EISSN

1552-5279

Publication Date

May 2008

Volume

4

Issue

3

Start / End Page

223 / 227

Location

United States

Related Subject Headings

  • Vitamin E
  • Neuropsychological Tests
  • Male
  • Humans
  • Geriatrics
  • Female
  • Drug Therapy, Combination
  • Dietary Supplements
  • Cognition
  • Brain