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The validity of the family history screen for assessing family history of mental disorders.

Publication ,  Journal Article
Milne, BJ; Caspi, A; Crump, R; Poulton, R; Rutter, M; Sears, MR; Moffitt, TE
Published in: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
January 2009

There is a need to collect psychiatric family history information quickly and economically (e.g., for genome-wide studies and primary care practice). We sought to evaluate the validity of family history reports using a brief screening instrument, the Family History Screen (FHS). We assessed the validity of parents' reports of seven psychiatric disorders in their adult children probands from the Dunedin Study (n = 959, 52% male), using the proband's diagnosis as the criterion outcome. We also investigated whether there were informant characteristics that enhanced accuracy of reporting or were associated with reporting biases. Using reports from multiple informants, we obtained sensitivities ranging from 31.7% (alcohol dependence) to 60.0% (conduct disorder) and specificities ranging from 76.0% (major depressive episode) to 97.1% (suicide attempt). There was little evidence that any informant characteristics enhanced accuracy of reporting. However, three reporting biases were found: the probability of reporting disorder in the proband was greater for informants with versus without a disorder, for female versus male informants, and for younger versus older informants. We conclude that the FHS is as valid as other family history instruments (e.g., the FH-RDC, FISC), and its brief administration time makes it a cost-effective method for collecting family history data. To avoid biasing results, researchers who aim to compare groups in terms of their family history should ensure that the informants reporting on these groups do not differ in terms of age, sex or personal history of disorder.

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Published In

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics

DOI

EISSN

1552-485X

ISSN

1552-4841

Publication Date

January 2009

Volume

150B

Issue

1

Start / End Page

41 / 49

Related Subject Headings

  • Mental Disorders
  • Medical History Taking
  • Male
  • Humans
  • Genetic Predisposition to Disease
  • Female
  • Adult
  • 3209 Neurosciences
  • 3202 Clinical sciences
  • 3105 Genetics
 

Citation

APA
Chicago
ICMJE
MLA
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Milne, B. J., Caspi, A., Crump, R., Poulton, R., Rutter, M., Sears, M. R., & Moffitt, T. E. (2009). The validity of the family history screen for assessing family history of mental disorders. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : The Official Publication of the International Society of Psychiatric Genetics, 150B(1), 41–49. https://doi.org/10.1002/ajmg.b.30764
Milne, B. J., A. Caspi, R. Crump, R. Poulton, M. Rutter, M. R. Sears, and T. E. Moffitt. “The validity of the family history screen for assessing family history of mental disorders.American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : The Official Publication of the International Society of Psychiatric Genetics 150B, no. 1 (January 2009): 41–49. https://doi.org/10.1002/ajmg.b.30764.
Milne BJ, Caspi A, Crump R, Poulton R, Rutter M, Sears MR, et al. The validity of the family history screen for assessing family history of mental disorders. American journal of medical genetics Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. 2009 Jan;150B(1):41–9.
Milne, B. J., et al. “The validity of the family history screen for assessing family history of mental disorders.American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : The Official Publication of the International Society of Psychiatric Genetics, vol. 150B, no. 1, Jan. 2009, pp. 41–49. Epmc, doi:10.1002/ajmg.b.30764.
Milne BJ, Caspi A, Crump R, Poulton R, Rutter M, Sears MR, Moffitt TE. The validity of the family history screen for assessing family history of mental disorders. American journal of medical genetics Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. 2009 Jan;150B(1):41–49.
Journal cover image

Published In

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics

DOI

EISSN

1552-485X

ISSN

1552-4841

Publication Date

January 2009

Volume

150B

Issue

1

Start / End Page

41 / 49

Related Subject Headings

  • Mental Disorders
  • Medical History Taking
  • Male
  • Humans
  • Genetic Predisposition to Disease
  • Female
  • Adult
  • 3209 Neurosciences
  • 3202 Clinical sciences
  • 3105 Genetics