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Adverse childhood experiences and adult risk factors for age-related disease: depression, inflammation, and clustering of metabolic risk markers.

Publication ,  Journal Article
Danese, A; Moffitt, TE; Harrington, H; Milne, BJ; Polanczyk, G; Pariante, CM; Poulton, R; Caspi, A
Published in: Archives of pediatrics & adolescent medicine
December 2009

To understand why children exposed to adverse psychosocial experiences are at elevated risk for age-related disease, such as cardiovascular disease, by testing whether adverse childhood experiences predict enduring abnormalities in stress-sensitive biological systems, namely, the nervous, immune, and endocrine/metabolic systems.A 32-year prospective longitudinal study of a representative birth cohort.New Zealand.A total of 1037 members of the Dunedin Multidisciplinary Health and Development Study. Main Exposures During their first decade of life, study members were assessed for exposure to 3 adverse psychosocial experiences: socioeconomic disadvantage, maltreatment, and social isolation.At age 32 years, study members were assessed for the presence of 3 age-related-disease risks: major depression, high inflammation levels (high-sensitivity C-reactive protein level >3 mg/L), and the clustering of metabolic risk biomarkers (overweight, high blood pressure, high total cholesterol, low high-density lipoprotein cholesterol, high glycated hemoglobin, and low maximum oxygen consumption levels.Children exposed to adverse psychosocial experiences were at elevated risk of depression, high inflammation levels, and clustering of metabolic risk markers. Children who had experienced socioeconomic disadvantage (incidence rate ratio, 1.89; 95% confidence interval, 1.36-2.62), maltreatment (1.81; 1.38-2.38), or social isolation (1.87; 1.38-2.51) had elevated age-related-disease risks in adulthood. The effects of adverse childhood experiences on age-related-disease risks in adulthood were nonredundant, cumulative, and independent of the influence of established developmental and concurrent risk factors.Children exposed to adverse psychosocial experiences have enduring emotional, immune, and metabolic abnormalities that contribute to explaining their elevated risk for age-related disease. The promotion of healthy psychosocial experiences for children is a necessary and potentially cost-effective target for the prevention of age-related disease.

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Published In

Archives of pediatrics & adolescent medicine

DOI

EISSN

1538-3628

ISSN

1072-4710

Publication Date

December 2009

Volume

163

Issue

12

Start / End Page

1135 / 1143

Related Subject Headings

  • Socioeconomic Factors
  • Social Isolation
  • Risk Factors
  • Prospective Studies
  • Proportional Hazards Models
  • Poisson Distribution
  • Pediatrics
  • Oxygen Consumption
  • Overweight
  • New Zealand
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Danese, A., Moffitt, T. E., Harrington, H., Milne, B. J., Polanczyk, G., Pariante, C. M., … Caspi, A. (2009). Adverse childhood experiences and adult risk factors for age-related disease: depression, inflammation, and clustering of metabolic risk markers. Archives of Pediatrics & Adolescent Medicine, 163(12), 1135–1143. https://doi.org/10.1001/archpediatrics.2009.214
Danese, Andrea, Terrie E. Moffitt, HonaLee Harrington, Barry J. Milne, Guilherme Polanczyk, Carmine M. Pariante, Richie Poulton, and Avshalom Caspi. “Adverse childhood experiences and adult risk factors for age-related disease: depression, inflammation, and clustering of metabolic risk markers.Archives of Pediatrics & Adolescent Medicine 163, no. 12 (December 2009): 1135–43. https://doi.org/10.1001/archpediatrics.2009.214.
Danese A, Moffitt TE, Harrington H, Milne BJ, Polanczyk G, Pariante CM, et al. Adverse childhood experiences and adult risk factors for age-related disease: depression, inflammation, and clustering of metabolic risk markers. Archives of pediatrics & adolescent medicine. 2009 Dec;163(12):1135–43.
Danese, Andrea, et al. “Adverse childhood experiences and adult risk factors for age-related disease: depression, inflammation, and clustering of metabolic risk markers.Archives of Pediatrics & Adolescent Medicine, vol. 163, no. 12, Dec. 2009, pp. 1135–43. Epmc, doi:10.1001/archpediatrics.2009.214.
Danese A, Moffitt TE, Harrington H, Milne BJ, Polanczyk G, Pariante CM, Poulton R, Caspi A. Adverse childhood experiences and adult risk factors for age-related disease: depression, inflammation, and clustering of metabolic risk markers. Archives of pediatrics & adolescent medicine. 2009 Dec;163(12):1135–1143.

Published In

Archives of pediatrics & adolescent medicine

DOI

EISSN

1538-3628

ISSN

1072-4710

Publication Date

December 2009

Volume

163

Issue

12

Start / End Page

1135 / 1143

Related Subject Headings

  • Socioeconomic Factors
  • Social Isolation
  • Risk Factors
  • Prospective Studies
  • Proportional Hazards Models
  • Poisson Distribution
  • Pediatrics
  • Oxygen Consumption
  • Overweight
  • New Zealand