Combined hyperspectral and spectral domain optical coherence tomography microscope for noninvasive hemodynamic imaging.
Publication
, Journal Article
Skala, MC; Fontanella, A; Hendargo, H; Dewhirst, MW; Izatt, JA
Published in: Opt Lett
February 1, 2009
We have combined hyperspectral imaging with spectral domain optical coherence tomography (SDOCT) to noninvasively image changes in hemoglobin saturation, blood flow, microvessel morphology, and sheer rate on the vessel wall with tumor growth. Changes in these hemodynamic variables were measured over 24 h in dorsal skin fold window chamber tumors. There was a strong correlation between volumetric flow and hemoglobin saturation (rho=0.89, p=9x10(-6), N=15) and a moderate correlation between shear rate on the vessel wall and hemoglobin saturation (rho=0.56, p=0.03, N=15).
Duke Scholars
Published In
Opt Lett
DOI
ISSN
0146-9592
Publication Date
February 1, 2009
Volume
34
Issue
3
Start / End Page
289 / 291
Location
United States
Related Subject Headings
- Tomography, Optical Coherence
- Systems Integration
- Spectrum Analysis
- Skin Neoplasms
- Sensitivity and Specificity
- Reproducibility of Results
- Optics
- Neovascularization, Pathologic
- Mice
- Hemoglobins
Citation
APA
Chicago
ICMJE
MLA
NLM
Skala, M. C., Fontanella, A., Hendargo, H., Dewhirst, M. W., & Izatt, J. A. (2009). Combined hyperspectral and spectral domain optical coherence tomography microscope for noninvasive hemodynamic imaging. Opt Lett, 34(3), 289–291. https://doi.org/10.1364/ol.34.000289
Skala, Melissa C., Andrew Fontanella, Hansford Hendargo, Mark W. Dewhirst, and Joseph A. Izatt. “Combined hyperspectral and spectral domain optical coherence tomography microscope for noninvasive hemodynamic imaging.” Opt Lett 34, no. 3 (February 1, 2009): 289–91. https://doi.org/10.1364/ol.34.000289.
Skala MC, Fontanella A, Hendargo H, Dewhirst MW, Izatt JA. Combined hyperspectral and spectral domain optical coherence tomography microscope for noninvasive hemodynamic imaging. Opt Lett. 2009 Feb 1;34(3):289–91.
Skala, Melissa C., et al. “Combined hyperspectral and spectral domain optical coherence tomography microscope for noninvasive hemodynamic imaging.” Opt Lett, vol. 34, no. 3, Feb. 2009, pp. 289–91. Pubmed, doi:10.1364/ol.34.000289.
Skala MC, Fontanella A, Hendargo H, Dewhirst MW, Izatt JA. Combined hyperspectral and spectral domain optical coherence tomography microscope for noninvasive hemodynamic imaging. Opt Lett. 2009 Feb 1;34(3):289–291.
Published In
Opt Lett
DOI
ISSN
0146-9592
Publication Date
February 1, 2009
Volume
34
Issue
3
Start / End Page
289 / 291
Location
United States
Related Subject Headings
- Tomography, Optical Coherence
- Systems Integration
- Spectrum Analysis
- Skin Neoplasms
- Sensitivity and Specificity
- Reproducibility of Results
- Optics
- Neovascularization, Pathologic
- Mice
- Hemoglobins