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Effect of calcitonin gene related peptide vs sodium nitroprusside to increase temperature in spontaneous canine tumours during local hyperthermia.

Publication ,  Journal Article
Poulson, JM; Vujaskovic, Z; Gaskin, AA; Larue, SM; Meyer, RE; Prescott, DM; Samulski, TV; Thrall, DE; Dewhirst, MW
Published in: Int J Hyperthermia
August 2004

The objectives of this study were to compare the effects of two vasodilators, sodium nitroprusside (SNP) and calcitonin gene-related peptide (CGRP) on mean arterial pressure (MAP), heart rate (HR) and temperatures in tumour and surrounding normal tissue during local hyperthermia treatment. Eleven tumour-bearing pet dogs with spontaneous soft tissue sarcomas were given SNP intravenously during local hyperthermia. The drug infusion rate was adjusted to maintain a 20% decrease in MAP. The median (95% CI) increase in the temperature distribution descriptors T(90) and T(50) was 0.2 degrees C (0.0-0.4 degrees C, p = 0.02) and 0.4 degrees C (0.1-0.7 degrees C, p = 0.02), respectively, in tumour. Normal subcutaneous tissue temperatures were mildly increased but remained below the threshold for thermal injury. The effects of CGRP were investigated in six tumour-bearing dogs following a protocol similar to that used for SNP. The median (interquartile (IQ) range) decrease in mean arterial pressure was 19% (15-26%) after CGRP administration and a significant increase was seen in tumour but not normal subcutaneous tissue temperatures. The median (95% CI) increase in the temperature distribution descriptors T(90) and T(50) was 0.5 degrees C (0.1-1.6 degrees C, p = 0.03) and 0.8 degrees C (0.1-1.6 degrees C, p = 0.13), respectively. Administration of SNP or CGRP did not result in local or systemic toxicity in tumour-bearing dogs. However, the magnitude of increase in tumour temperatures was not sufficient to improve the likelihood of increased response rates. Therefore, there is little justification for translation of this approach to human trials using conventional local hyperthermia.

Duke Scholars

Published In

Int J Hyperthermia

DOI

ISSN

0265-6736

Publication Date

August 2004

Volume

20

Issue

5

Start / End Page

477 / 489

Location

England

Related Subject Headings

  • Vasodilator Agents
  • Soft Tissue Neoplasms
  • Sarcoma
  • Oncology & Carcinogenesis
  • Nitroprusside
  • Hyperthermia, Induced
  • Dogs
  • Dog Diseases
  • Combined Modality Therapy
  • Calcitonin Gene-Related Peptide
 

Citation

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Poulson, J. M., Vujaskovic, Z., Gaskin, A. A., Larue, S. M., Meyer, R. E., Prescott, D. M., … Dewhirst, M. W. (2004). Effect of calcitonin gene related peptide vs sodium nitroprusside to increase temperature in spontaneous canine tumours during local hyperthermia. Int J Hyperthermia, 20(5), 477–489. https://doi.org/10.1080/0265673032000173906
Poulson, J. M., Z. Vujaskovic, A. A. Gaskin, S. M. Larue, R. E. Meyer, D. M. Prescott, T. V. Samulski, D. E. Thrall, and M. W. Dewhirst. “Effect of calcitonin gene related peptide vs sodium nitroprusside to increase temperature in spontaneous canine tumours during local hyperthermia.Int J Hyperthermia 20, no. 5 (August 2004): 477–89. https://doi.org/10.1080/0265673032000173906.
Poulson JM, Vujaskovic Z, Gaskin AA, Larue SM, Meyer RE, Prescott DM, et al. Effect of calcitonin gene related peptide vs sodium nitroprusside to increase temperature in spontaneous canine tumours during local hyperthermia. Int J Hyperthermia. 2004 Aug;20(5):477–89.
Poulson, J. M., et al. “Effect of calcitonin gene related peptide vs sodium nitroprusside to increase temperature in spontaneous canine tumours during local hyperthermia.Int J Hyperthermia, vol. 20, no. 5, Aug. 2004, pp. 477–89. Pubmed, doi:10.1080/0265673032000173906.
Poulson JM, Vujaskovic Z, Gaskin AA, Larue SM, Meyer RE, Prescott DM, Samulski TV, Thrall DE, Dewhirst MW. Effect of calcitonin gene related peptide vs sodium nitroprusside to increase temperature in spontaneous canine tumours during local hyperthermia. Int J Hyperthermia. 2004 Aug;20(5):477–489.
Journal cover image

Published In

Int J Hyperthermia

DOI

ISSN

0265-6736

Publication Date

August 2004

Volume

20

Issue

5

Start / End Page

477 / 489

Location

England

Related Subject Headings

  • Vasodilator Agents
  • Soft Tissue Neoplasms
  • Sarcoma
  • Oncology & Carcinogenesis
  • Nitroprusside
  • Hyperthermia, Induced
  • Dogs
  • Dog Diseases
  • Combined Modality Therapy
  • Calcitonin Gene-Related Peptide