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HIF-1 and tumour radiosensitivity.

Publication ,  Journal Article
Moeller, BJ; Dewhirst, MW
Published in: Br J Cancer
July 3, 2006
Published version (DOI) Link to item

Hypoxia-inducible factor-1 (HIF-1) plays important roles in regulating radiosensitivity, making it a potentially promising target for tumour radiosensitisation. Here, we discuss the rationale for, and the potential pitfalls of, combining HIF-1 blockade with radiotherapy. In doing so, we describe clinical scenarios in which HIF-1 inhibition might optimise tumour radiosensitivity.

Duke Scholars

Mark Wesley Dewhirst
Author Mark Wesley Dewhirst Radiation Oncology
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Published In

Br J Cancer

DOI

10.1038/sj.bjc.6603201

ISSN

0007-0920

Publication Date

July 3, 2006

Volume

95

Issue

1

Start / End Page

1 / 5

Location

England

Related Subject Headings

  • Radiation Tolerance
  • Oncology & Carcinogenesis
  • Neoplasms
  • Hypoxia-Inducible Factor 1
  • Humans
  • Gene Expression Regulation, Neoplastic
  • Cell Hypoxia
  • 3211 Oncology and carcinogenesis
  • 1117 Public Health and Health Services
  • 1112 Oncology and Carcinogenesis
 

Citation

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Moeller, B. J., & Dewhirst, M. W. (2006). HIF-1 and tumour radiosensitivity. Br J Cancer, 95(1), 1–5. https://doi.org/10.1038/sj.bjc.6603201
Moeller, B. J., and M. W. Dewhirst. “HIF-1 and tumour radiosensitivity.” Br J Cancer 95, no. 1 (July 3, 2006): 1–5. https://doi.org/10.1038/sj.bjc.6603201.
Moeller BJ, Dewhirst MW. HIF-1 and tumour radiosensitivity. Br J Cancer. 2006 Jul 3;95(1):1–5.
Moeller, B. J., and M. W. Dewhirst. “HIF-1 and tumour radiosensitivity.” Br J Cancer, vol. 95, no. 1, July 2006, pp. 1–5. Pubmed, doi:10.1038/sj.bjc.6603201.
Moeller BJ, Dewhirst MW. HIF-1 and tumour radiosensitivity. Br J Cancer. 2006 Jul 3;95(1):1–5.

Published In

Br J Cancer

DOI

10.1038/sj.bjc.6603201

ISSN

0007-0920

Publication Date

July 3, 2006

Volume

95

Issue

1

Start / End Page

1 / 5

Location

England

Related Subject Headings

  • Radiation Tolerance
  • Oncology & Carcinogenesis
  • Neoplasms
  • Hypoxia-Inducible Factor 1
  • Humans
  • Gene Expression Regulation, Neoplastic
  • Cell Hypoxia
  • 3211 Oncology and carcinogenesis
  • 1117 Public Health and Health Services
  • 1112 Oncology and Carcinogenesis