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Quantitative optical spectroscopy can identify long-term local tumor control in irradiated murine head and neck xenografts.

Publication ,  Journal Article
Vishwanath, K; Klein, D; Chang, K; Schroeder, T; Dewhirst, MW; Ramanujam, N
Published in: J Biomed Opt
2009

Noninvasive and longitudinal monitoring of tumor oxygenation status using quantitative diffuse reflectance spectroscopy is used to test whether a final treatment outcome could be estimated from early optical signatures in a murine model of head and neck cancer when treated with radiation. Implanted tumors in the flank of 23 nude mice are exposed to 39 Gy of radiation, while 11 animals exposed to sham irradiation serve as controls. Diffuse optical reflectance is measured from the tumors at baseline (prior to irradiation) and then serially until 17 days posttreatment. The fastest and greatest increase in baseline-corrected blood oxygen saturation levels are observed from the animals that show complete tumor regression with no recurrence 90 days postirradiation, relative to both untreated and treated animals with local recurrences. These increases in saturation are observed starting 5 days posttreatment and last up to 17 days posttreatment. This preclinical study demonstrates that diffuse reflectance spectroscopy could provide a practical method far more effective than the growth delay assay to prognosticate treatment outcome in solid tumors and may hold significant translational promise.

Duke Scholars

Published In

J Biomed Opt

DOI

EISSN

1560-2281

Publication Date

2009

Volume

14

Issue

5

Start / End Page

054051

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Spectrum Analysis
  • Sensitivity and Specificity
  • Reproducibility of Results
  • Optics
  • Mice, Nude
  • Mice
  • Humans
  • Head and Neck Neoplasms
  • Diagnosis, Computer-Assisted
 

Citation

APA
Chicago
ICMJE
MLA
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Vishwanath, K., Klein, D., Chang, K., Schroeder, T., Dewhirst, M. W., & Ramanujam, N. (2009). Quantitative optical spectroscopy can identify long-term local tumor control in irradiated murine head and neck xenografts. J Biomed Opt, 14(5), 054051. https://doi.org/10.1117/1.3251013
Vishwanath, Karthik, Daniel Klein, Kevin Chang, Thies Schroeder, Mark W. Dewhirst, and Nimmi Ramanujam. “Quantitative optical spectroscopy can identify long-term local tumor control in irradiated murine head and neck xenografts.J Biomed Opt 14, no. 5 (2009): 054051. https://doi.org/10.1117/1.3251013.
Vishwanath K, Klein D, Chang K, Schroeder T, Dewhirst MW, Ramanujam N. Quantitative optical spectroscopy can identify long-term local tumor control in irradiated murine head and neck xenografts. J Biomed Opt. 2009;14(5):054051.
Vishwanath, Karthik, et al. “Quantitative optical spectroscopy can identify long-term local tumor control in irradiated murine head and neck xenografts.J Biomed Opt, vol. 14, no. 5, 2009, p. 054051. Pubmed, doi:10.1117/1.3251013.
Vishwanath K, Klein D, Chang K, Schroeder T, Dewhirst MW, Ramanujam N. Quantitative optical spectroscopy can identify long-term local tumor control in irradiated murine head and neck xenografts. J Biomed Opt. 2009;14(5):054051.

Published In

J Biomed Opt

DOI

EISSN

1560-2281

Publication Date

2009

Volume

14

Issue

5

Start / End Page

054051

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Spectrum Analysis
  • Sensitivity and Specificity
  • Reproducibility of Results
  • Optics
  • Mice, Nude
  • Mice
  • Humans
  • Head and Neck Neoplasms
  • Diagnosis, Computer-Assisted