Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel
Journal cover image

Levels of alpha-synuclein mRNA in sporadic Parkinson disease patients.

Publication ,  Journal Article
Chiba-Falek, O; Lopez, GJ; Nussbaum, RL
Published in: Mov Disord
October 2006

Lewy bodies, the pathological hallmark of Parkinson's disease (PD), consist largely of alpha-synuclein, a 14.5-kDa presynaptic neuronal protein implicated in familial PD. An increased copy number and elevated expression of wild-type alpha-synuclein (SNCA) has been shown to cause early-onset familial PD. However, it is not clear whether increased alpha-synuclein expression also plays a role in the pathogenesis of sporadic disease. In the current study, we analyzed the levels of SNCA-mRNA in affected brains of sporadic PD patients. We compared the levels of steady state SNCA-mRNA in 7 sporadic PD brain samples and 7 normal controls using real-time polymerase chain reaction of RNA extracted from mid-brain tissue, including the substantia nigra. Despite that there is neuronal loss in the substantia nigra of PD brains, overall the SNCA-mRNA levels were increased in PD brains an average of nearly fourfold over normal control mid-brain, although there was much greater variability in samples from PD patients compared to controls. Frontal cortex samples from selected individuals were also analyzed. SNCA-mRNA levels were not significantly changed in PD frontal cortex compared to controls. These results suggest that elevated expression levels of SNCA-mRNA are found in the affected regions of PD brain and support the hypothesis that increases in alpha-synuclein expression is associated, among other factors, with the development of sporadic PD.

Duke Scholars

Published In

Mov Disord

DOI

ISSN

0885-3185

Publication Date

October 2006

Volume

21

Issue

10

Start / End Page

1703 / 1708

Location

United States

Related Subject Headings

  • alpha-Synuclein
  • Substantia Nigra
  • Reference Values
  • RNA, Messenger
  • Parkinson Disease
  • Neurology & Neurosurgery
  • Mesencephalon
  • Male
  • Humans
  • Genetic Predisposition to Disease
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Chiba-Falek, O., Lopez, G. J., & Nussbaum, R. L. (2006). Levels of alpha-synuclein mRNA in sporadic Parkinson disease patients. Mov Disord, 21(10), 1703–1708. https://doi.org/10.1002/mds.21007
Chiba-Falek, Ornit, Grisel J. Lopez, and Robert L. Nussbaum. “Levels of alpha-synuclein mRNA in sporadic Parkinson disease patients.Mov Disord 21, no. 10 (October 2006): 1703–8. https://doi.org/10.1002/mds.21007.
Chiba-Falek O, Lopez GJ, Nussbaum RL. Levels of alpha-synuclein mRNA in sporadic Parkinson disease patients. Mov Disord. 2006 Oct;21(10):1703–8.
Chiba-Falek, Ornit, et al. “Levels of alpha-synuclein mRNA in sporadic Parkinson disease patients.Mov Disord, vol. 21, no. 10, Oct. 2006, pp. 1703–08. Pubmed, doi:10.1002/mds.21007.
Chiba-Falek O, Lopez GJ, Nussbaum RL. Levels of alpha-synuclein mRNA in sporadic Parkinson disease patients. Mov Disord. 2006 Oct;21(10):1703–1708.
Journal cover image

Published In

Mov Disord

DOI

ISSN

0885-3185

Publication Date

October 2006

Volume

21

Issue

10

Start / End Page

1703 / 1708

Location

United States

Related Subject Headings

  • alpha-Synuclein
  • Substantia Nigra
  • Reference Values
  • RNA, Messenger
  • Parkinson Disease
  • Neurology & Neurosurgery
  • Mesencephalon
  • Male
  • Humans
  • Genetic Predisposition to Disease