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White matter lesion volumes and caudate volumes in late-life depression.

Publication ,  Journal Article
Hannestad, J; Taylor, WD; McQuoid, DR; Payne, ME; Krishnan, KRR; Steffens, DC; Macfall, JR
Published in: Int J Geriatr Psychiatry
December 2006

BACKGROUND: Decreased caudate volumes and increased white matter lesions (WMLs) are associated both with aging and late-life depression, but the relationship between the two is unclear. We examined the association between WML and caudate volume, hypothesizing there would be a negative association, which would be stronger for WMLs located in anterior regions. We additionally hypothesized that this association would be stronger in depressed subjects. METHOD: This MRI study included 182 elderly depressed and 64 elderly control subjects. Our imaging analysis procedures divided the brain into anterior and posterior halves. WML volume in each half was calculated, as were left and right caudate volumes. A statistical model incorporating WML volumes, age, total brain volume, diagnosis, and gender was used to examine caudate volumes. RESULTS: WML volume was negatively associated with total and right caudate volume. This association was stronger for WMLs in the anterior half of the brain. Anterior WML volume was additionally negatively associated with right caudate volume in depressed subjects, but not in controls. CONCLUSIONS: Using unadjusted levels of significance, WML volume is negatively associated with right caudate volume in both older populations, but with left caudate volume only in depressed individuals. When statistical corrections for multiple comparisons are used, the finding is limited to a negative association between WML volume and right caudate volume, primarily in depressed subjects. This study demonstrates one mechanism by which WMLs may disrupt frontostriatal circuits.

Duke Scholars

Published In

Int J Geriatr Psychiatry

DOI

ISSN

0885-6230

Publication Date

December 2006

Volume

21

Issue

12

Start / End Page

1193 / 1198

Location

England

Related Subject Headings

  • Male
  • Magnetic Resonance Imaging
  • Image Processing, Computer-Assisted
  • Humans
  • Geriatrics
  • Female
  • Depressive Disorder, Major
  • Cross-Sectional Studies
  • Caudate Nucleus
  • Brain Mapping
 

Citation

APA
Chicago
ICMJE
MLA
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Hannestad, J., Taylor, W. D., McQuoid, D. R., Payne, M. E., Krishnan, K. R. R., Steffens, D. C., & Macfall, J. R. (2006). White matter lesion volumes and caudate volumes in late-life depression. Int J Geriatr Psychiatry, 21(12), 1193–1198. https://doi.org/10.1002/gps.1640
Hannestad, Jonas, Warren D. Taylor, Douglas R. McQuoid, Martha E. Payne, K Ranga R. Krishnan, David C. Steffens, and James R. Macfall. “White matter lesion volumes and caudate volumes in late-life depression.Int J Geriatr Psychiatry 21, no. 12 (December 2006): 1193–98. https://doi.org/10.1002/gps.1640.
Hannestad J, Taylor WD, McQuoid DR, Payne ME, Krishnan KRR, Steffens DC, et al. White matter lesion volumes and caudate volumes in late-life depression. Int J Geriatr Psychiatry. 2006 Dec;21(12):1193–8.
Hannestad, Jonas, et al. “White matter lesion volumes and caudate volumes in late-life depression.Int J Geriatr Psychiatry, vol. 21, no. 12, Dec. 2006, pp. 1193–98. Pubmed, doi:10.1002/gps.1640.
Hannestad J, Taylor WD, McQuoid DR, Payne ME, Krishnan KRR, Steffens DC, Macfall JR. White matter lesion volumes and caudate volumes in late-life depression. Int J Geriatr Psychiatry. 2006 Dec;21(12):1193–1198.
Journal cover image

Published In

Int J Geriatr Psychiatry

DOI

ISSN

0885-6230

Publication Date

December 2006

Volume

21

Issue

12

Start / End Page

1193 / 1198

Location

England

Related Subject Headings

  • Male
  • Magnetic Resonance Imaging
  • Image Processing, Computer-Assisted
  • Humans
  • Geriatrics
  • Female
  • Depressive Disorder, Major
  • Cross-Sectional Studies
  • Caudate Nucleus
  • Brain Mapping