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Monte Carlo-based inverse model for calculating tissue optical properties. Part I: Theory and validation on synthetic phantoms.

Publication ,  Journal Article
Palmer, GM; Ramanujam, N
Published in: Appl Opt
February 10, 2006

A flexible and fast Monte Carlo-based model of diffuse reflectance has been developed for the extraction of the absorption and scattering properties of turbid media, such as human tissues. This method is valid for a wide range of optical properties and is easily adaptable to existing probe geometries, provided a single phantom calibration measurement is made. A condensed Monte Carlo method was used to speed up the forward simulations. This model was validated by use of two sets of liquid-tissue phantoms containing Nigrosin or hemoglobin as absorbers and polystyrene spheres as scatterers. The phantoms had a wide range of absorption (0-20 cm(-1)) and reduced scattering coefficients (7-33 cm(-1)). Mie theory and a spectrophotometer were used to determine the absorption and reduced scattering coefficients of the phantoms. The diffuse reflectance spectra of the phantoms were measured over a wavelength range of 350-850 nm. It was found that optical properties could be extracted from the experimentally measured diffuse reflectance spectra with an average error of 3% or less for phantoms containing hemoglobin and 12% or less for phantoms containing Nigrosin.

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Published In

Appl Opt

DOI

ISSN

1559-128X

Publication Date

February 10, 2006

Volume

45

Issue

5

Start / End Page

1062 / 1071

Location

United States

Related Subject Headings

  • Spectrum Analysis
  • Refractometry
  • Phantoms, Imaging
  • Optics
  • Monte Carlo Method
  • Models, Statistical
  • Models, Biological
  • Humans
  • Connective Tissue
  • Animals
 

Citation

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Palmer, G. M., & Ramanujam, N. (2006). Monte Carlo-based inverse model for calculating tissue optical properties. Part I: Theory and validation on synthetic phantoms. Appl Opt, 45(5), 1062–1071. https://doi.org/10.1364/ao.45.001062
Palmer, Gregory M., and Nirmala Ramanujam. “Monte Carlo-based inverse model for calculating tissue optical properties. Part I: Theory and validation on synthetic phantoms.Appl Opt 45, no. 5 (February 10, 2006): 1062–71. https://doi.org/10.1364/ao.45.001062.
Palmer, Gregory M., and Nirmala Ramanujam. “Monte Carlo-based inverse model for calculating tissue optical properties. Part I: Theory and validation on synthetic phantoms.Appl Opt, vol. 45, no. 5, Feb. 2006, pp. 1062–71. Pubmed, doi:10.1364/ao.45.001062.
Journal cover image

Published In

Appl Opt

DOI

ISSN

1559-128X

Publication Date

February 10, 2006

Volume

45

Issue

5

Start / End Page

1062 / 1071

Location

United States

Related Subject Headings

  • Spectrum Analysis
  • Refractometry
  • Phantoms, Imaging
  • Optics
  • Monte Carlo Method
  • Models, Statistical
  • Models, Biological
  • Humans
  • Connective Tissue
  • Animals