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Predictors of adverse events among pregnant smokers exposed in a nicotine replacement therapy trial.

Publication ,  Journal Article
Swamy, GK; Roelands, JJ; Peterson, BL; Fish, LJ; Oncken, CA; Pletsch, PK; Myers, ER; Whitecar, PW; Pollak, KI
Published in: Am J Obstet Gynecol
October 2009

OBJECTIVE: The purpose of this study was to determine the contribution of randomization to nicotine replacement therapy (NRT), sociodemographic and psychosocial factors, and pregnancy and medical history to serious perinatal adverse events among pregnant smokers. STUDY DESIGN: We performed a retrospective review of all medical records for participants in the Baby Steps Trial. Data that were abstracted from 157 records were combined with baseline characteristics for logistic regression modeling of serious adverse events and adjusted for covariates. RESULTS: Serious adverse events occurred in 17% (9/52 pregnancies) and 31% (33/105 pregnancies) of participants in the control and NRT arms, respectively. Black race, adverse pregnancy history, and use of analgesic medication during pregnancy were significant predictors (P = .02, .04, and .01, respectively). Remaining covariates, which included randomization to NRT, were not statistically significant. CONCLUSION: Although race, poor pregnancy history, and use of analgesics were associated with serious adverse events, randomization to NRT during pregnancy was not a significant factor. Further research is needed to examine the safety of analgesic medications during pregnancy.

Duke Scholars

Published In

Am J Obstet Gynecol

DOI

EISSN

1097-6868

Publication Date

October 2009

Volume

201

Issue

4

Start / End Page

354.e1 / 354.e7

Location

United States

Related Subject Headings

  • Young Adult
  • Stress, Psychological
  • Socioeconomic Factors
  • Smoking Prevention
  • Smoking Cessation
  • Self Concept
  • Risk Factors
  • Retrospective Studies
  • Premature Birth
  • Pregnancy Outcome
 

Citation

APA
Chicago
ICMJE
MLA
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Swamy, G. K., Roelands, J. J., Peterson, B. L., Fish, L. J., Oncken, C. A., Pletsch, P. K., … Pollak, K. I. (2009). Predictors of adverse events among pregnant smokers exposed in a nicotine replacement therapy trial. Am J Obstet Gynecol, 201(4), 354.e1-354.e7. https://doi.org/10.1016/j.ajog.2009.06.006
Swamy, Geeta K., Jennifer J. Roelands, Bercedis L. Peterson, Laura J. Fish, Cheryl A. Oncken, Pamela K. Pletsch, Evan R. Myers, Paul W. Whitecar, and Kathryn I. Pollak. “Predictors of adverse events among pregnant smokers exposed in a nicotine replacement therapy trial.Am J Obstet Gynecol 201, no. 4 (October 2009): 354.e1-354.e7. https://doi.org/10.1016/j.ajog.2009.06.006.
Swamy GK, Roelands JJ, Peterson BL, Fish LJ, Oncken CA, Pletsch PK, et al. Predictors of adverse events among pregnant smokers exposed in a nicotine replacement therapy trial. Am J Obstet Gynecol. 2009 Oct;201(4):354.e1-354.e7.
Swamy, Geeta K., et al. “Predictors of adverse events among pregnant smokers exposed in a nicotine replacement therapy trial.Am J Obstet Gynecol, vol. 201, no. 4, Oct. 2009, pp. 354.e1-354.e7. Pubmed, doi:10.1016/j.ajog.2009.06.006.
Swamy GK, Roelands JJ, Peterson BL, Fish LJ, Oncken CA, Pletsch PK, Myers ER, Whitecar PW, Pollak KI. Predictors of adverse events among pregnant smokers exposed in a nicotine replacement therapy trial. Am J Obstet Gynecol. 2009 Oct;201(4):354.e1-354.e7.
Journal cover image

Published In

Am J Obstet Gynecol

DOI

EISSN

1097-6868

Publication Date

October 2009

Volume

201

Issue

4

Start / End Page

354.e1 / 354.e7

Location

United States

Related Subject Headings

  • Young Adult
  • Stress, Psychological
  • Socioeconomic Factors
  • Smoking Prevention
  • Smoking Cessation
  • Self Concept
  • Risk Factors
  • Retrospective Studies
  • Premature Birth
  • Pregnancy Outcome