Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel
Journal cover image

Comparison between ticlopidine and clopidogrel in patients undergoing primary stenting in acute myocardial infarction: results from the CADILLAC trial.

Publication ,  Journal Article
Lansky, AJ; Tsuchiya, Y; Brener, M; Mehran, R; Cristea, E; Pietras, C; Grines, CL; Cox, DA; Garcia, E; Tcheng, JE; Guagliumi, G; Stuckey, T ...
Published in: Catheter Cardiovasc Interv
December 1, 2008

OBJECTIVE: The aim of this article is to examine whether clopidogrel and ticlopidine treatments produce similar clinical outcomes for patients receiving primary stenting for acute myocardial infarction (AMI). BACKGROUND: Prior studies have yielded conflicting results on the relative safety and efficacy of clopidogrel and ticlopidine after stent implantation, warranting an evaluation in primary stenting for AMI. METHODS: In the multicenter, prospective CADILLAC trial, patients undergoing primary infarct stenting were treated at operator discretion with either ticlopidine (931 patients) or clopidogrel (163 patients) and then followed for 1 year. Baseline clinical and angiographic characteristics were comparable except for baseline TIMI 0/1 flow (72.5% clopidogrel vs. 63.9% ticlopidine, P = 0.04). RESULTS: Patients receiving clopidogrel had more recurrent ischemia in hospital (6.1 vs. 2.8%, P = 0.02) and at 30 days (10.5 vs. 5.8%, P = 0.02), more moderate and severe bleeding at 30 days (7.4 vs. 2.7%, P = 0.002), and similar rates of stent thrombosis out to 1 year (P = 0.11). By multivariable analysis, clopidogrel use was an independent predictor for recurrent ischemia in hospital (P = 0.0002), and at 30 days (P = 0.012); and of moderate and severe bleeding in hospital (P = 0.002), and at 30 days (P = 0.001). CONCLUSIONS: Despite thienopyridines similarities, their efficacy may be different within the first 30 days of primary stenting for AMI. A prospective, randomized trial is required to confirm these findings.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Catheter Cardiovasc Interv

DOI

EISSN

1522-726X

Publication Date

December 1, 2008

Volume

72

Issue

7

Start / End Page

917 / 924

Location

United States

Related Subject Headings

  • United States
  • Treatment Outcome
  • Time Factors
  • Ticlopidine
  • Thrombosis
  • Stents
  • Risk Assessment
  • Retrospective Studies
  • Randomized Controlled Trials as Topic
  • Platelet Aggregation Inhibitors
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Lansky, A. J., Tsuchiya, Y., Brener, M., Mehran, R., Cristea, E., Pietras, C., … Stone, G. W. (2008). Comparison between ticlopidine and clopidogrel in patients undergoing primary stenting in acute myocardial infarction: results from the CADILLAC trial. Catheter Cardiovasc Interv, 72(7), 917–924. https://doi.org/10.1002/ccd.21714
Lansky, Alexandra J., Yoshihiro Tsuchiya, Micheal Brener, Roxana Mehran, Ecaterina Cristea, Cody Pietras, Cindy L. Grines, et al. “Comparison between ticlopidine and clopidogrel in patients undergoing primary stenting in acute myocardial infarction: results from the CADILLAC trial.Catheter Cardiovasc Interv 72, no. 7 (December 1, 2008): 917–24. https://doi.org/10.1002/ccd.21714.
Lansky AJ, Tsuchiya Y, Brener M, Mehran R, Cristea E, Pietras C, et al. Comparison between ticlopidine and clopidogrel in patients undergoing primary stenting in acute myocardial infarction: results from the CADILLAC trial. Catheter Cardiovasc Interv. 2008 Dec 1;72(7):917–24.
Lansky, Alexandra J., et al. “Comparison between ticlopidine and clopidogrel in patients undergoing primary stenting in acute myocardial infarction: results from the CADILLAC trial.Catheter Cardiovasc Interv, vol. 72, no. 7, Dec. 2008, pp. 917–24. Pubmed, doi:10.1002/ccd.21714.
Lansky AJ, Tsuchiya Y, Brener M, Mehran R, Cristea E, Pietras C, Grines CL, Cox DA, Garcia E, Tcheng JE, Guagliumi G, Stuckey T, Turco M, Carroll JD, Rutherford BD, Leon MB, Moses J, Stone GW. Comparison between ticlopidine and clopidogrel in patients undergoing primary stenting in acute myocardial infarction: results from the CADILLAC trial. Catheter Cardiovasc Interv. 2008 Dec 1;72(7):917–924.
Journal cover image

Published In

Catheter Cardiovasc Interv

DOI

EISSN

1522-726X

Publication Date

December 1, 2008

Volume

72

Issue

7

Start / End Page

917 / 924

Location

United States

Related Subject Headings

  • United States
  • Treatment Outcome
  • Time Factors
  • Ticlopidine
  • Thrombosis
  • Stents
  • Risk Assessment
  • Retrospective Studies
  • Randomized Controlled Trials as Topic
  • Platelet Aggregation Inhibitors