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Regulation of V(D)J recombination by E-protein transcription factors.

Publication ,  Journal Article
Jones, ME; Zhuang, Y
Published in: Adv Exp Med Biol
2009

Extensive study of the E-proteins E2A and HEB duringlymphocyte development has revealed various functions for these bHLH transcription factors in regulating V(D)J recombination in both B- and T-cells. The study of E-proteins in mammals began with the identification of E2A by its ability to bind immunoglobulin heavy and light chain enhancers. Subsequent analysis has identified numerous roles for E2A and HEB at the immunoglobulin and T-cell receptor loci. E-protein targets also include the rag genes and other factors critical for recombination and for regulation of the developmental windows when cells undergo recombination. E-proteins appear to be master regulators that coordinate antigen receptor gene rearrangement and expression. This chapter focuses on how E-proteins regulate V(D)J recombination by activating transcription, initiating rearrangement and driving differentiation during B- and T-cell development.

Duke Scholars

Published In

Adv Exp Med Biol

DOI

ISSN

0065-2598

Publication Date

2009

Volume

650

Start / End Page

148 / 156

Location

United States

Related Subject Headings

  • VDJ Recombinases
  • Recombination, Genetic
  • Genes, T-Cell Receptor
  • Genes, Immunoglobulin
  • General & Internal Medicine
  • Gene Rearrangement, T-Lymphocyte
  • Gene Rearrangement, B-Lymphocyte
  • Basic Helix-Loop-Helix Transcription Factors
  • Animals
  • 32 Biomedical and clinical sciences
 

Citation

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ICMJE
MLA
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Jones, M. E., & Zhuang, Y. (2009). Regulation of V(D)J recombination by E-protein transcription factors. Adv Exp Med Biol, 650, 148–156. https://doi.org/10.1007/978-1-4419-0296-2_12
Jones, Mary Elizabeth, and Yuan Zhuang. “Regulation of V(D)J recombination by E-protein transcription factors.Adv Exp Med Biol 650 (2009): 148–56. https://doi.org/10.1007/978-1-4419-0296-2_12.
Jones ME, Zhuang Y. Regulation of V(D)J recombination by E-protein transcription factors. Adv Exp Med Biol. 2009;650:148–56.
Jones, Mary Elizabeth, and Yuan Zhuang. “Regulation of V(D)J recombination by E-protein transcription factors.Adv Exp Med Biol, vol. 650, 2009, pp. 148–56. Pubmed, doi:10.1007/978-1-4419-0296-2_12.
Jones ME, Zhuang Y. Regulation of V(D)J recombination by E-protein transcription factors. Adv Exp Med Biol. 2009;650:148–156.

Published In

Adv Exp Med Biol

DOI

ISSN

0065-2598

Publication Date

2009

Volume

650

Start / End Page

148 / 156

Location

United States

Related Subject Headings

  • VDJ Recombinases
  • Recombination, Genetic
  • Genes, T-Cell Receptor
  • Genes, Immunoglobulin
  • General & Internal Medicine
  • Gene Rearrangement, T-Lymphocyte
  • Gene Rearrangement, B-Lymphocyte
  • Basic Helix-Loop-Helix Transcription Factors
  • Animals
  • 32 Biomedical and clinical sciences