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Respiratory-triggered three-dimensional T2-weighted MR cholangiography after injection of gadoxetate disodium: is it still reliable?

Publication ,  Journal Article
Ringe, KI; Gupta, RT; Brady, CM; Massey, CM; Hahn, A; Galanski, M; Merkle, EM; Lotz, J
Published in: Radiology
May 2010

PURPOSE: To test the null hypothesis that there is no quantitative or qualitative difference between respiratory-triggered three-dimensional (3D) T2-weighted magnetic resonance (MR) cholangiography performed before or after administration of gadoxetate disodium. MATERIALS AND METHODS: For this retrospective HIPAA-compliant dual-center study, institutional review board approval was obtained, and a waiver of informed consent was granted. Between July and December 2008, 60 patients (age range, 18-82 years) who were referred for liver MR imaging with gadoxetate disodium underwent respiratory-triggered 3D MR cholangiography before and immediately after completion of portal venous phase contrast material-enhanced T1-weighted MR imaging. Quantitative signal-to-noise ratio (SNR) measurements were obtained in the extrahepatic biliary tract in both MR cholangiographic data sets in each patient. Qualitative assessment was performed by four readers with a four-point scale to assess the depiction of extra- and intrahepatic ducts up to the third order. Statistical analysis consisted of a one-sided Wilcoxon signed rank test, with a P value of less than .05 indicating a significant difference. RESULTS: There was a significant decrease in mean SNR in the MR cholangiographic data set after injection of gadoxetate disodium. SNR was 96 + or - 50 [standard deviation] and 78 + or - 47 before and after contrast media administration, respectively (P < .0001). For all readers, qualitative differences were most obvious in the depiction of the common bile duct and second- and third-order biliary branches, with the precontrast MR cholangiographic data sets being preferred (P < .0001). Precontrast data sets were also significantly preferred in the assessment of the right and left hepatic ducts by all readers. CONCLUSION: Gadoxetate disodium adversely affects respiratory-triggered 3D MR cholangiography, both qualitatively and quantitatively. We recommend that such a sequence be performed before injection of gadoxetate disodium.

Duke Scholars

Published In

Radiology

DOI

EISSN

1527-1315

Publication Date

May 2010

Volume

255

Issue

2

Start / End Page

451 / 458

Location

United States

Related Subject Headings

  • Statistics, Nonparametric
  • Retrospective Studies
  • Respiratory-Gated Imaging Techniques
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Male
  • Liver Diseases
  • Imaging, Three-Dimensional
  • Humans
  • Gadolinium DTPA
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Ringe, K. I., Gupta, R. T., Brady, C. M., Massey, C. M., Hahn, A., Galanski, M., … Lotz, J. (2010). Respiratory-triggered three-dimensional T2-weighted MR cholangiography after injection of gadoxetate disodium: is it still reliable? Radiology, 255(2), 451–458. https://doi.org/10.1148/radiol.10091130
Ringe, Kristina I., Rajan T. Gupta, Christopher M. Brady, Christopher M. Massey, Andreas Hahn, Michael Galanski, Elmar M. Merkle, and Joachim Lotz. “Respiratory-triggered three-dimensional T2-weighted MR cholangiography after injection of gadoxetate disodium: is it still reliable?Radiology 255, no. 2 (May 2010): 451–58. https://doi.org/10.1148/radiol.10091130.
Ringe KI, Gupta RT, Brady CM, Massey CM, Hahn A, Galanski M, et al. Respiratory-triggered three-dimensional T2-weighted MR cholangiography after injection of gadoxetate disodium: is it still reliable? Radiology. 2010 May;255(2):451–8.
Ringe, Kristina I., et al. “Respiratory-triggered three-dimensional T2-weighted MR cholangiography after injection of gadoxetate disodium: is it still reliable?Radiology, vol. 255, no. 2, May 2010, pp. 451–58. Pubmed, doi:10.1148/radiol.10091130.
Ringe KI, Gupta RT, Brady CM, Massey CM, Hahn A, Galanski M, Merkle EM, Lotz J. Respiratory-triggered three-dimensional T2-weighted MR cholangiography after injection of gadoxetate disodium: is it still reliable? Radiology. 2010 May;255(2):451–458.

Published In

Radiology

DOI

EISSN

1527-1315

Publication Date

May 2010

Volume

255

Issue

2

Start / End Page

451 / 458

Location

United States

Related Subject Headings

  • Statistics, Nonparametric
  • Retrospective Studies
  • Respiratory-Gated Imaging Techniques
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Male
  • Liver Diseases
  • Imaging, Three-Dimensional
  • Humans
  • Gadolinium DTPA