Skip to main content
Journal cover image

Two-dimensional analysis of ventricular fibrillation in the guinea pig.

Publication ,  Journal Article
Gopalakrishnan, M; Malkin, RA
Published in: Journal of electrocardiology
April 2003

Cardiac arrhythmias are undesirable electrical activity in the heart. Ventricular fibrillation (VF) is a fatal cardiac arrhythmia and is characterized by the breakdown of organized electrical activity in the ventricular myocardium. However, little is known about VF, partially because it is difficult to study and understand an apparently disorganized activity. One method for discovering the nature of VF is processing the epicardial electrical signals by using cardiac mapping techniques. These techniques involve the study of propagation patterns seen in VF. In this project, we used guinea pigs to study the spatial organization of the epicardial electrical activity during VF. VF was induced in 9 open chest guinea pigs and epicardial electrode data were acquired by using a square array of 192 electrodes for 4 seconds every minute. The mean correlation length and dominant frequency were measured in each recorded segment. Correlation length is a measure of the spatial order in a system and dominant frequency is the frequency corresponding to the spectral maximum. The mean correlation length was found to vary between 1-7 mm and the dominant frequency was in the range of 1-14 Hz. This study suggests that guinea pig VF exhibits a level of organization equivalent to or greater than that seen in previous studies.

Duke Scholars

Published In

Journal of electrocardiology

DOI

EISSN

1532-8430

ISSN

0022-0736

Publication Date

April 2003

Volume

36

Issue

2

Start / End Page

147 / 153

Related Subject Headings

  • Ventricular Fibrillation
  • Heart
  • Guinea Pigs
  • Electrodes
  • Electric Conductivity
  • Computing Methodologies
  • Cardiovascular System & Hematology
  • Animals
  • Analysis of Variance
  • 3201 Cardiovascular medicine and haematology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Gopalakrishnan, M., & Malkin, R. A. (2003). Two-dimensional analysis of ventricular fibrillation in the guinea pig. Journal of Electrocardiology, 36(2), 147–153. https://doi.org/10.1054/jelc.2003.50012
Gopalakrishnan, Meera, and Robert A. Malkin. “Two-dimensional analysis of ventricular fibrillation in the guinea pig.Journal of Electrocardiology 36, no. 2 (April 2003): 147–53. https://doi.org/10.1054/jelc.2003.50012.
Gopalakrishnan M, Malkin RA. Two-dimensional analysis of ventricular fibrillation in the guinea pig. Journal of electrocardiology. 2003 Apr;36(2):147–53.
Gopalakrishnan, Meera, and Robert A. Malkin. “Two-dimensional analysis of ventricular fibrillation in the guinea pig.Journal of Electrocardiology, vol. 36, no. 2, Apr. 2003, pp. 147–53. Epmc, doi:10.1054/jelc.2003.50012.
Gopalakrishnan M, Malkin RA. Two-dimensional analysis of ventricular fibrillation in the guinea pig. Journal of electrocardiology. 2003 Apr;36(2):147–153.
Journal cover image

Published In

Journal of electrocardiology

DOI

EISSN

1532-8430

ISSN

0022-0736

Publication Date

April 2003

Volume

36

Issue

2

Start / End Page

147 / 153

Related Subject Headings

  • Ventricular Fibrillation
  • Heart
  • Guinea Pigs
  • Electrodes
  • Electric Conductivity
  • Computing Methodologies
  • Cardiovascular System & Hematology
  • Animals
  • Analysis of Variance
  • 3201 Cardiovascular medicine and haematology