Skip to main content
Journal cover image

Suppression of renal disease and mortality in the female NZB x NZW F1 mouse model of systemic lupus erythematosus (SLE) by chenodeoxycholic acid.

Publication ,  Journal Article
Suwannaroj, S; Lagoo, A; McMurray, RW
Published in: Lupus
2001

The objective of this study was to examine the effects of ursodeoxycholic (UDCA) and chenodeoxycholic acid (CDCA) on autoimmune disease in the NZB x NZW F1 (B/W) mouse model of systemic lupus erythematosus (SLE). The development of murine lupus was assessed in female B/W mice given UDCA or CDCA. At 6 week intervals mice were examined for weight change, albuminuria, anti-DNA antibody and total IgG levels. Morbidity and mortality were assessed daily. UDCA- and CDCA-treated mice were examined at 24 weeks of age for serum cytokines, lymphocyte phenotype, and in vitro cytokine production after immunization with DNP-KLH. Liver and kidneys were examined histopathologically. The administration of UDCA and CDCA was tolerated without side effects. Weight gain in UDCA- or CDCA-treated and control mice was identical through 24 weeks of age. CDCA, but not UDCA, suppressed the development of renal disease. CDCA-treated B/W mice also had improved survival compared to UDCA-treated or control B/W mice. There were no significant effects of CDCA on anti-DNA antibodies, serum total IgG, or other immunologic parameters. CDCA-treated mice had lower serum IFN-gamma concentrations compared to control and UDCA-treated mice. The bile acid, CDCA, significantly inhibited the development of renal disease and modestly prolonged lifespan in the female B/W mouse model of SLE. Suppression of glomerulonephritis was associated with lower serum IFNgamma concentrations. Further investigation is needed to verify potential mechanisms of action, but these findings suggest that bile acids may alter the development or progression of autoimmunity.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Lupus

DOI

ISSN

0961-2033

Publication Date

2001

Volume

10

Issue

8

Start / End Page

562 / 567

Location

England

Related Subject Headings

  • Ursodeoxycholic Acid
  • Urodynamics
  • Uremia
  • Survival Rate
  • Spleen
  • Mice, Inbred NZB
  • Mice
  • Lupus Nephritis
  • Liver
  • Kidney
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Suwannaroj, S., Lagoo, A., & McMurray, R. W. (2001). Suppression of renal disease and mortality in the female NZB x NZW F1 mouse model of systemic lupus erythematosus (SLE) by chenodeoxycholic acid. Lupus, 10(8), 562–567. https://doi.org/10.1191/096120301701549697
Suwannaroj, S., A. Lagoo, and R. W. McMurray. “Suppression of renal disease and mortality in the female NZB x NZW F1 mouse model of systemic lupus erythematosus (SLE) by chenodeoxycholic acid.Lupus 10, no. 8 (2001): 562–67. https://doi.org/10.1191/096120301701549697.
Suwannaroj, S., et al. “Suppression of renal disease and mortality in the female NZB x NZW F1 mouse model of systemic lupus erythematosus (SLE) by chenodeoxycholic acid.Lupus, vol. 10, no. 8, 2001, pp. 562–67. Pubmed, doi:10.1191/096120301701549697.
Journal cover image

Published In

Lupus

DOI

ISSN

0961-2033

Publication Date

2001

Volume

10

Issue

8

Start / End Page

562 / 567

Location

England

Related Subject Headings

  • Ursodeoxycholic Acid
  • Urodynamics
  • Uremia
  • Survival Rate
  • Spleen
  • Mice, Inbred NZB
  • Mice
  • Lupus Nephritis
  • Liver
  • Kidney