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Characteristics of a neutralizing monoclonal antibody to the HIV envelope glycoprotein.

Publication ,  Journal Article
Skinner, MA; Ting, R; Langlois, AJ; Weinhold, KJ; Lyerly, HK; Javaherian, K; Matthews, TJ
Published in: Aids Res Hum Retroviruses
June 1988

We have studied the biologic and physical properties of a monoclonal antibody that binds to gp120, the exterior envelope glycoprotein of the human immunodeficiency virus (HIV) strain HTLV-IIIB. Designated 9284, the antibody possesses viral neutralizing activity and inhibits syncytium formation by infected cells. The antibody recognized a region of the polypeptide backbone previously described as an important neutralizing epitope. This region lies 307-330 residues from amino terminus of the glycoprotein. We have compared the biologic and physical properties of this antibody to those of the recently described 0.5 beta monoclonal antibody to gp120. The 0.5 beta antibody was biologically more potent and bound an epitope slightly downstream to that of the 9284 antibody. The antibodies did not differ significantly in their affinity for gp120. In competition studies, the 0.5 beta antibody was displaced by the 9284 antibody, but the binding of the latter was unaffected by 0.5 beta.

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Published In

Aids Res Hum Retroviruses

DOI

ISSN

0889-2229

Publication Date

June 1988

Volume

4

Issue

3

Start / End Page

187 / 197

Location

United States

Related Subject Headings

  • Virology
  • Viral Envelope Proteins
  • Neutralization Tests
  • Humans
  • HIV
  • Glycoproteins
  • Epitopes
  • Antibodies, Monoclonal
  • 1103 Clinical Sciences
 

Citation

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Skinner, M. A., Ting, R., Langlois, A. J., Weinhold, K. J., Lyerly, H. K., Javaherian, K., & Matthews, T. J. (1988). Characteristics of a neutralizing monoclonal antibody to the HIV envelope glycoprotein. Aids Res Hum Retroviruses, 4(3), 187–197. https://doi.org/10.1089/aid.1988.4.187
Skinner, M. A., R. Ting, A. J. Langlois, K. J. Weinhold, H. K. Lyerly, K. Javaherian, and T. J. Matthews. “Characteristics of a neutralizing monoclonal antibody to the HIV envelope glycoprotein.Aids Res Hum Retroviruses 4, no. 3 (June 1988): 187–97. https://doi.org/10.1089/aid.1988.4.187.
Skinner MA, Ting R, Langlois AJ, Weinhold KJ, Lyerly HK, Javaherian K, et al. Characteristics of a neutralizing monoclonal antibody to the HIV envelope glycoprotein. Aids Res Hum Retroviruses. 1988 Jun;4(3):187–97.
Skinner, M. A., et al. “Characteristics of a neutralizing monoclonal antibody to the HIV envelope glycoprotein.Aids Res Hum Retroviruses, vol. 4, no. 3, June 1988, pp. 187–97. Pubmed, doi:10.1089/aid.1988.4.187.
Skinner MA, Ting R, Langlois AJ, Weinhold KJ, Lyerly HK, Javaherian K, Matthews TJ. Characteristics of a neutralizing monoclonal antibody to the HIV envelope glycoprotein. Aids Res Hum Retroviruses. 1988 Jun;4(3):187–197.
Journal cover image

Published In

Aids Res Hum Retroviruses

DOI

ISSN

0889-2229

Publication Date

June 1988

Volume

4

Issue

3

Start / End Page

187 / 197

Location

United States

Related Subject Headings

  • Virology
  • Viral Envelope Proteins
  • Neutralization Tests
  • Humans
  • HIV
  • Glycoproteins
  • Epitopes
  • Antibodies, Monoclonal
  • 1103 Clinical Sciences