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Transmission of HIV by antigen presenting cells during T-cell activation: prevention by 3'-azido-3'-deoxythymidine.

Publication ,  Journal Article
Lyerly, HK; Cohen, OJ; Weinhold, KJ
Published in: AIDS Res Hum Retroviruses
1987

Tetanus toxoid (TT) reactive CD4+ cells were infected with HTLV-IIIB and exposed to TT at various times throughout a 7-day interval. Acute infection per se failed to produce overt cytopathology. However, exposure of infected cells to TT resulted in a rapid loss of cell viability, an increase in viral p24 expression, and a decline in T-cell blastogenesis. To determine whether HIV infection of antigen presenting cells (APC) could impact on T-cell activation, virus infected APC were utilized to present TT to responsive CD4+ cells. Use of infected APC produced effects similar to antigen stimulation of infected T-cells. These results suggest that the conditions of antigen presentation during T-cell activation may provide an excellent opportunity for virus transmission which may produce maximal immune dysfunction. However, preincubating antigen specific T-cells with the virostatic agent 3'-azido-3'-deoxythymidine (AZT) could prevent most of these effects.

Duke Scholars

Published In

AIDS Res Hum Retroviruses

DOI

ISSN

0889-2229

Publication Date

1987

Volume

3

Issue

1

Start / End Page

87 / 94

Location

United States

Related Subject Headings

  • Zidovudine
  • Virology
  • Thymidine
  • Tetanus Toxoid
  • T-Lymphocytes
  • Radioimmunoassay
  • Models, Biological
  • Lymphocyte Activation
  • Humans
  • HIV
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Lyerly, H. K., Cohen, O. J., & Weinhold, K. J. (1987). Transmission of HIV by antigen presenting cells during T-cell activation: prevention by 3'-azido-3'-deoxythymidine. AIDS Res Hum Retroviruses, 3(1), 87–94. https://doi.org/10.1089/aid.1987.3.87
Lyerly, H. K., O. J. Cohen, and K. J. Weinhold. “Transmission of HIV by antigen presenting cells during T-cell activation: prevention by 3'-azido-3'-deoxythymidine.AIDS Res Hum Retroviruses 3, no. 1 (1987): 87–94. https://doi.org/10.1089/aid.1987.3.87.
Lyerly HK, Cohen OJ, Weinhold KJ. Transmission of HIV by antigen presenting cells during T-cell activation: prevention by 3'-azido-3'-deoxythymidine. AIDS Res Hum Retroviruses. 1987;3(1):87–94.
Lyerly, H. K., et al. “Transmission of HIV by antigen presenting cells during T-cell activation: prevention by 3'-azido-3'-deoxythymidine.AIDS Res Hum Retroviruses, vol. 3, no. 1, 1987, pp. 87–94. Pubmed, doi:10.1089/aid.1987.3.87.
Lyerly HK, Cohen OJ, Weinhold KJ. Transmission of HIV by antigen presenting cells during T-cell activation: prevention by 3'-azido-3'-deoxythymidine. AIDS Res Hum Retroviruses. 1987;3(1):87–94.
Journal cover image

Published In

AIDS Res Hum Retroviruses

DOI

ISSN

0889-2229

Publication Date

1987

Volume

3

Issue

1

Start / End Page

87 / 94

Location

United States

Related Subject Headings

  • Zidovudine
  • Virology
  • Thymidine
  • Tetanus Toxoid
  • T-Lymphocytes
  • Radioimmunoassay
  • Models, Biological
  • Lymphocyte Activation
  • Humans
  • HIV