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Anti-GP 120 antibodies from HIV seropositive individuals mediate broadly reactive anti-HIV ADCC.

Publication ,  Journal Article
Lyerly, HK; Reed, DL; Matthews, TJ; Langlois, AJ; Ahearne, PA; Petteway, SR; Weinhold, KJ
Published in: AIDS Res Hum Retroviruses
1987

Cytophilic antibodies which mediate antibody dependent cellular cytotoxicity (ADCC) against envelope antigens of human immunodeficiency virus (HIV) can be found in seropositive individuals. In these experiments, sera from a wide spectrum of HIV infected patients ranging from asymptomatic to overt acquired immunodeficiency syndrome (AIDS) were shown to contain high titers of antibodies that mediate ADCC. Not only did patient antibodies bind to surface expressed viral antigens and mediate ADCC against cells chronically infected with human T-lymphotropic virus type IIIB (HTLV-IIIB), but also against cells infected with the divergent HTLV-IIIRF2 and HTLV-IIIMN viral isolates. Similar results were obtained with target cells bearing purified GP 120 from HTLV-IIIB and HTLV-IIIRF2, indicating that a major portion of the activity was mediated by anti-GP 120 antibodies. Consistent with this was the ability to absorb most of the group-specific ADCC activity from the serum of an HIV infected individual using affinity columns bearing purified HTLV-IIIB GP 120. The finding that human antibodies reactive against the HIV envelope glycoprotein mediate ADCC against cells chronically infected with divergent strains of HIV will have important implications in designing rational approaches to passive and active immunotherapy.

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Published In

AIDS Res Hum Retroviruses

DOI

ISSN

0889-2229

Publication Date

1987

Volume

3

Issue

4

Start / End Page

409 / 422

Location

United States

Related Subject Headings

  • Virology
  • Viral Envelope Proteins
  • Retroviridae Proteins
  • Neutralization Tests
  • Humans
  • HIV Seropositivity
  • HIV Envelope Protein gp120
  • HIV Antibodies
  • HIV
  • Flow Cytometry
 

Citation

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Lyerly, H. K., Reed, D. L., Matthews, T. J., Langlois, A. J., Ahearne, P. A., Petteway, S. R., & Weinhold, K. J. (1987). Anti-GP 120 antibodies from HIV seropositive individuals mediate broadly reactive anti-HIV ADCC. AIDS Res Hum Retroviruses, 3(4), 409–422. https://doi.org/10.1089/aid.1987.3.409
Lyerly, H. K., D. L. Reed, T. J. Matthews, A. J. Langlois, P. A. Ahearne, S. R. Petteway, and K. J. Weinhold. “Anti-GP 120 antibodies from HIV seropositive individuals mediate broadly reactive anti-HIV ADCC.AIDS Res Hum Retroviruses 3, no. 4 (1987): 409–22. https://doi.org/10.1089/aid.1987.3.409.
Lyerly HK, Reed DL, Matthews TJ, Langlois AJ, Ahearne PA, Petteway SR, et al. Anti-GP 120 antibodies from HIV seropositive individuals mediate broadly reactive anti-HIV ADCC. AIDS Res Hum Retroviruses. 1987;3(4):409–22.
Lyerly, H. K., et al. “Anti-GP 120 antibodies from HIV seropositive individuals mediate broadly reactive anti-HIV ADCC.AIDS Res Hum Retroviruses, vol. 3, no. 4, 1987, pp. 409–22. Pubmed, doi:10.1089/aid.1987.3.409.
Lyerly HK, Reed DL, Matthews TJ, Langlois AJ, Ahearne PA, Petteway SR, Weinhold KJ. Anti-GP 120 antibodies from HIV seropositive individuals mediate broadly reactive anti-HIV ADCC. AIDS Res Hum Retroviruses. 1987;3(4):409–422.
Journal cover image

Published In

AIDS Res Hum Retroviruses

DOI

ISSN

0889-2229

Publication Date

1987

Volume

3

Issue

4

Start / End Page

409 / 422

Location

United States

Related Subject Headings

  • Virology
  • Viral Envelope Proteins
  • Retroviridae Proteins
  • Neutralization Tests
  • Humans
  • HIV Seropositivity
  • HIV Envelope Protein gp120
  • HIV Antibodies
  • HIV
  • Flow Cytometry