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Low morbidity and mortality for bronchoplastic procedures with and without induction therapy.

Publication ,  Journal Article
Burfeind, WR; D'Amico, TA; Toloza, EM; Wolfe, WG; Harpole, DH
Published in: Ann Thorac Surg
August 2005

BACKGROUND: The safety of bronchoplastic procedures after induction chemoradiotherapy is uncertain. This study examines short- and long-term outcomes after bronchoplastic procedures with and without induction therapy. METHODS: Between January 1997 and September 2004, more than 1,300 anatomic pulmonary resections for cancer were performed at a single institution. Of these, 73 patients required either sleeve lobectomy (57) or bronchoplasty (16), and were retrospectively analyzed. Nineteen patients (26%) received induction therapy; 15 received chemotherapy and radiation therapy and 4 received chemotherapy alone. Fifty-four patients underwent the bronchoplastic procedure without induction therapy. Mortality and early and late morbidity were analyzed. RESULTS: Mean follow-up was 25 months. Histology was nonsmall cell cancer in 62 (85%), carcinoid in 8 (11%), and renal cell cancer, schwannoma, and mucoepidermoid cancer in 1 patient each. There were 2 (2.7%) 30-day deaths, both in the group not receiving induction therapy. Of the surviving 71 patients, 70 had functional reconstructions at last follow-up. The overall 30-day complication rate was 30% (19 of 54) in patients not receiving induction therapy (no bronchopleural fistulas) and 42% (8 of 19) occurring in those receiving induction therapy (1 bronchopleural fistula). The long-term complication rate was 20% (11 of 54) among patients not receiving induction therapy and 5% (1 of 19) among those receiving induction therapy (completion pneumonectomy). There were no bronchovascular complications. Interventional bronchoscopy was required in 7 patients not receiving induction therapy, and was required in none of the patients receiving induction therapy. CONCLUSIONS: Anatomic pulmonary resections utilizing bronchoplastic techniques can be performed with low morbidity and mortality rates even after induction therapy.

Duke Scholars

Published In

Ann Thorac Surg

DOI

EISSN

1552-6259

Publication Date

August 2005

Volume

80

Issue

2

Start / End Page

418 / 421

Location

Netherlands

Related Subject Headings

  • Retrospective Studies
  • Respiratory System
  • Radiotherapy, Adjuvant
  • Pneumonectomy
  • Neoadjuvant Therapy
  • Middle Aged
  • Male
  • Lung Neoplasms
  • Humans
  • Female
 

Citation

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Chicago
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Burfeind, W. R., D’Amico, T. A., Toloza, E. M., Wolfe, W. G., & Harpole, D. H. (2005). Low morbidity and mortality for bronchoplastic procedures with and without induction therapy. Ann Thorac Surg, 80(2), 418–421. https://doi.org/10.1016/j.athoracsur.2005.02.058
Burfeind, William R., Thomas A. D’Amico, Eric M. Toloza, Walter G. Wolfe, and David H. Harpole. “Low morbidity and mortality for bronchoplastic procedures with and without induction therapy.Ann Thorac Surg 80, no. 2 (August 2005): 418–21. https://doi.org/10.1016/j.athoracsur.2005.02.058.
Burfeind WR, D’Amico TA, Toloza EM, Wolfe WG, Harpole DH. Low morbidity and mortality for bronchoplastic procedures with and without induction therapy. Ann Thorac Surg. 2005 Aug;80(2):418–21.
Burfeind, William R., et al. “Low morbidity and mortality for bronchoplastic procedures with and without induction therapy.Ann Thorac Surg, vol. 80, no. 2, Aug. 2005, pp. 418–21. Pubmed, doi:10.1016/j.athoracsur.2005.02.058.
Burfeind WR, D’Amico TA, Toloza EM, Wolfe WG, Harpole DH. Low morbidity and mortality for bronchoplastic procedures with and without induction therapy. Ann Thorac Surg. 2005 Aug;80(2):418–421.
Journal cover image

Published In

Ann Thorac Surg

DOI

EISSN

1552-6259

Publication Date

August 2005

Volume

80

Issue

2

Start / End Page

418 / 421

Location

Netherlands

Related Subject Headings

  • Retrospective Studies
  • Respiratory System
  • Radiotherapy, Adjuvant
  • Pneumonectomy
  • Neoadjuvant Therapy
  • Middle Aged
  • Male
  • Lung Neoplasms
  • Humans
  • Female