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Incidence of benign disease in patients that underwent resection for presumed pancreatic cancer diagnosed by endoscopic ultrasonography (EUS) and fine-needle aspiration (FNA).

Publication ,  Journal Article
de la Fuente, SG; Ceppa, EP; Reddy, SK; Clary, BM; Tyler, DS; Pappas, TN
Published in: J Gastrointest Surg
July 2010

INTRODUCTION: The lack of accurate markers makes preoperative differentiation between pancreatic cancer and non-malignant head lesions clinically challenging. In this study, we investigated the incidence of benign disease in patients that underwent resection for presumed pancreatic cancer diagnosed by EUS and EUS-guided FNA. METHODS: Medical records of consecutive patients who underwent pancreaticoduodenectomy at Duke University were reviewed. Demographics, clinicopathologic characteristics, preoperative imaging, EUS, EUS-guided FNA, and postoperative outcomes were analyzed. RESULTS: Seven percent of the total 494 patients studied were found to have benign disease on postoperative pathology. Fifty-nine percent of these patients with benign disease underwent preoperative EUS. EUS was positive for a head mass in 70%, demonstrated enlarged lymph nodes in 27%, and showed signs concerning for vascular invasion in 13%. FNA was suspicious or indeterminate for cancer in 63% of patients. Postoperative complications occurred in 47% and one patient died after surgery. The overall pancreatic leak rate was 15%. CONCLUSIONS: Even with aggressive use of preoperative evaluation, there is still a small subset of patients where malignancy cannot be excluded without pancreaticoduodenectomy.

Duke Scholars

Published In

J Gastrointest Surg

DOI

EISSN

1873-4626

Publication Date

July 2010

Volume

14

Issue

7

Start / End Page

1139 / 1142

Location

Netherlands

Related Subject Headings

  • Surgery
  • Preoperative Period
  • Postoperative Complications
  • Pancreaticoduodenectomy
  • Pancreatic Neoplasms
  • Pancreatic Diseases
  • Middle Aged
  • Male
  • Humans
  • Female
 

Citation

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de la Fuente, S. G., Ceppa, E. P., Reddy, S. K., Clary, B. M., Tyler, D. S., & Pappas, T. N. (2010). Incidence of benign disease in patients that underwent resection for presumed pancreatic cancer diagnosed by endoscopic ultrasonography (EUS) and fine-needle aspiration (FNA). J Gastrointest Surg, 14(7), 1139–1142. https://doi.org/10.1007/s11605-010-1196-9
Journal cover image

Published In

J Gastrointest Surg

DOI

EISSN

1873-4626

Publication Date

July 2010

Volume

14

Issue

7

Start / End Page

1139 / 1142

Location

Netherlands

Related Subject Headings

  • Surgery
  • Preoperative Period
  • Postoperative Complications
  • Pancreaticoduodenectomy
  • Pancreatic Neoplasms
  • Pancreatic Diseases
  • Middle Aged
  • Male
  • Humans
  • Female