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Incidence of benign disease in patients that underwent resection for presumed pancreatic cancer diagnosed by endoscopic ultrasonography (EUS) and fine-needle aspiration (FNA).

Publication ,  Journal Article
de la Fuente, SG; Ceppa, EP; Reddy, SK; Clary, BM; Tyler, DS; Pappas, TN
Published in: J Gastrointest Surg
July 2010

INTRODUCTION: The lack of accurate markers makes preoperative differentiation between pancreatic cancer and non-malignant head lesions clinically challenging. In this study, we investigated the incidence of benign disease in patients that underwent resection for presumed pancreatic cancer diagnosed by EUS and EUS-guided FNA. METHODS: Medical records of consecutive patients who underwent pancreaticoduodenectomy at Duke University were reviewed. Demographics, clinicopathologic characteristics, preoperative imaging, EUS, EUS-guided FNA, and postoperative outcomes were analyzed. RESULTS: Seven percent of the total 494 patients studied were found to have benign disease on postoperative pathology. Fifty-nine percent of these patients with benign disease underwent preoperative EUS. EUS was positive for a head mass in 70%, demonstrated enlarged lymph nodes in 27%, and showed signs concerning for vascular invasion in 13%. FNA was suspicious or indeterminate for cancer in 63% of patients. Postoperative complications occurred in 47% and one patient died after surgery. The overall pancreatic leak rate was 15%. CONCLUSIONS: Even with aggressive use of preoperative evaluation, there is still a small subset of patients where malignancy cannot be excluded without pancreaticoduodenectomy.

Duke Scholars

Published In

J Gastrointest Surg

DOI

EISSN

1873-4626

Publication Date

July 2010

Volume

14

Issue

7

Start / End Page

1139 / 1142

Location

United States

Related Subject Headings

  • Surgery
  • Preoperative Period
  • Postoperative Complications
  • Pancreaticoduodenectomy
  • Pancreatic Neoplasms
  • Pancreatic Diseases
  • Middle Aged
  • Male
  • Humans
  • Female
 

Citation

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de la Fuente, S. G., Ceppa, E. P., Reddy, S. K., Clary, B. M., Tyler, D. S., & Pappas, T. N. (2010). Incidence of benign disease in patients that underwent resection for presumed pancreatic cancer diagnosed by endoscopic ultrasonography (EUS) and fine-needle aspiration (FNA). J Gastrointest Surg, 14(7), 1139–1142. https://doi.org/10.1007/s11605-010-1196-9
Fuente, Sebastian G. de la, Eugene P. Ceppa, Srinevas K. Reddy, Bryan M. Clary, Douglas S. Tyler, and Theodore N. Pappas. “Incidence of benign disease in patients that underwent resection for presumed pancreatic cancer diagnosed by endoscopic ultrasonography (EUS) and fine-needle aspiration (FNA).J Gastrointest Surg 14, no. 7 (July 2010): 1139–42. https://doi.org/10.1007/s11605-010-1196-9.
de la Fuente, Sebastian G., et al. “Incidence of benign disease in patients that underwent resection for presumed pancreatic cancer diagnosed by endoscopic ultrasonography (EUS) and fine-needle aspiration (FNA).J Gastrointest Surg, vol. 14, no. 7, July 2010, pp. 1139–42. Pubmed, doi:10.1007/s11605-010-1196-9.
de la Fuente SG, Ceppa EP, Reddy SK, Clary BM, Tyler DS, Pappas TN. Incidence of benign disease in patients that underwent resection for presumed pancreatic cancer diagnosed by endoscopic ultrasonography (EUS) and fine-needle aspiration (FNA). J Gastrointest Surg. 2010 Jul;14(7):1139–1142.
Journal cover image

Published In

J Gastrointest Surg

DOI

EISSN

1873-4626

Publication Date

July 2010

Volume

14

Issue

7

Start / End Page

1139 / 1142

Location

United States

Related Subject Headings

  • Surgery
  • Preoperative Period
  • Postoperative Complications
  • Pancreaticoduodenectomy
  • Pancreatic Neoplasms
  • Pancreatic Diseases
  • Middle Aged
  • Male
  • Humans
  • Female