Trimethoprim-sulfamethoxazole vs. ampicillin in the treatment of experimental meningitis due to Streptococcus pneumoniae.
Publication
, Journal Article
Durack, DT; Corey, GR; Perfect, JR
Published in: Rev Infect Dis
1982
When given in combination, both trimethoprim and sulfamethoxazole penetrated well into the cerebrospinal fluid of rabbits with experimental pneumococcal meningitis, reaching concentrations that should have been adequate for synergistic killing of Streptococcus pneumoniae. However, trimethoprim-sulfamethoxazole was less effective than ampicillin in the treatment of this experimental infection. The effect of the combination on pneumococci in vivo was bacteriostatic rather than bactericidal, possibly because the number of pneumococci in the cerebrospinal fluid of the rabbits at the start of treatment was larger than that in the inoculum used for in vitro sensitivity tests.
Duke Scholars
Published In
Rev Infect Dis
DOI
ISSN
0162-0886
Publication Date
1982
Volume
4
Issue
2
Start / End Page
311 / 314
Location
United States
Related Subject Headings
- Trimethoprim, Sulfamethoxazole Drug Combination
- Trimethoprim
- Time Factors
- Sulfamethoxazole
- Rabbits
- Microbial Sensitivity Tests
- Meningitis, Pneumococcal
- Drug Combinations
- Animals
- Ampicillin
Citation
APA
Chicago
ICMJE
MLA
NLM
Durack, D. T., Corey, G. R., & Perfect, J. R. (1982). Trimethoprim-sulfamethoxazole vs. ampicillin in the treatment of experimental meningitis due to Streptococcus pneumoniae. Rev Infect Dis, 4(2), 311–314. https://doi.org/10.1093/clinids/4.2.311
Durack, D. T., G. R. Corey, and J. R. Perfect. “Trimethoprim-sulfamethoxazole vs. ampicillin in the treatment of experimental meningitis due to Streptococcus pneumoniae.” Rev Infect Dis 4, no. 2 (1982): 311–14. https://doi.org/10.1093/clinids/4.2.311.
Durack DT, Corey GR, Perfect JR. Trimethoprim-sulfamethoxazole vs. ampicillin in the treatment of experimental meningitis due to Streptococcus pneumoniae. Rev Infect Dis. 1982;4(2):311–4.
Durack, D. T., et al. “Trimethoprim-sulfamethoxazole vs. ampicillin in the treatment of experimental meningitis due to Streptococcus pneumoniae.” Rev Infect Dis, vol. 4, no. 2, 1982, pp. 311–14. Pubmed, doi:10.1093/clinids/4.2.311.
Durack DT, Corey GR, Perfect JR. Trimethoprim-sulfamethoxazole vs. ampicillin in the treatment of experimental meningitis due to Streptococcus pneumoniae. Rev Infect Dis. 1982;4(2):311–314.
Published In
Rev Infect Dis
DOI
ISSN
0162-0886
Publication Date
1982
Volume
4
Issue
2
Start / End Page
311 / 314
Location
United States
Related Subject Headings
- Trimethoprim, Sulfamethoxazole Drug Combination
- Trimethoprim
- Time Factors
- Sulfamethoxazole
- Rabbits
- Microbial Sensitivity Tests
- Meningitis, Pneumococcal
- Drug Combinations
- Animals
- Ampicillin