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Initial low-dose gentamicin for Staphylococcus aureus bacteremia and endocarditis is nephrotoxic.

Publication ,  Journal Article
Cosgrove, SE; Vigliani, GA; Fowler, VG; Abrutyn, E; Corey, GR; Levine, DP; Rupp, ME; Chambers, HF; Karchmer, AW; Boucher, HW
Published in: Clin Infect Dis
March 15, 2009

BACKGROUND: The safety of adding initial low-dose gentamicin to antistaphylococcal penicillins or vancomycin for treatment of suspected Staphylococcus aureus native valve endocarditis is unknown. This study evaluated the association between this practice and nephrotoxicity. METHODS: We performed a prospective cohort study of safety data from a randomized, controlled trial of therapy for S. aureus bacteremia and native valve infective endocarditis involving 236 patients from 44 hospitals in 4 countries. Patients either received standard therapy (antistaphylococcal penicillin or vancomycin) plus initial low-dose gentamicin (n=116) or received daptomycin monotherapy (n = 120). We measured renal adverse events and clinically significant decreased creatinine clearance in patients (1) in the original randomized study arms and (2) who received any initial low-dose gentamicin either, as a study medication or

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Published In

Clin Infect Dis

DOI

EISSN

1537-6591

Publication Date

March 15, 2009

Volume

48

Issue

6

Start / End Page

713 / 721

Location

United States

Related Subject Headings

  • Young Adult
  • Vancomycin
  • Staphylococcus aureus
  • Staphylococcal Infections
  • Prospective Studies
  • Penicillins
  • Middle Aged
  • Microbiology
  • Metabolic Clearance Rate
  • Male
 

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Cosgrove, S. E., Vigliani, G. A., Fowler, V. G., Abrutyn, E., Corey, G. R., Levine, D. P., … Boucher, H. W. (2009). Initial low-dose gentamicin for Staphylococcus aureus bacteremia and endocarditis is nephrotoxic. Clin Infect Dis, 48(6), 713–721. https://doi.org/10.1086/597031
Cosgrove, Sara E., Gloria A. Vigliani, Vance G. Fowler, Elias Abrutyn, G Ralph Corey, Donald P. Levine, Mark E. Rupp, Henry F. Chambers, Adolf W. Karchmer, and Helen W. Boucher. “Initial low-dose gentamicin for Staphylococcus aureus bacteremia and endocarditis is nephrotoxic.Clin Infect Dis 48, no. 6 (March 15, 2009): 713–21. https://doi.org/10.1086/597031.
Cosgrove SE, Vigliani GA, Fowler VG, Abrutyn E, Corey GR, Levine DP, et al. Initial low-dose gentamicin for Staphylococcus aureus bacteremia and endocarditis is nephrotoxic. Clin Infect Dis. 2009 Mar 15;48(6):713–21.
Cosgrove, Sara E., et al. “Initial low-dose gentamicin for Staphylococcus aureus bacteremia and endocarditis is nephrotoxic.Clin Infect Dis, vol. 48, no. 6, Mar. 2009, pp. 713–21. Pubmed, doi:10.1086/597031.
Cosgrove SE, Vigliani GA, Fowler VG, Abrutyn E, Corey GR, Levine DP, Rupp ME, Chambers HF, Karchmer AW, Boucher HW. Initial low-dose gentamicin for Staphylococcus aureus bacteremia and endocarditis is nephrotoxic. Clin Infect Dis. 2009 Mar 15;48(6):713–721.
Journal cover image

Published In

Clin Infect Dis

DOI

EISSN

1537-6591

Publication Date

March 15, 2009

Volume

48

Issue

6

Start / End Page

713 / 721

Location

United States

Related Subject Headings

  • Young Adult
  • Vancomycin
  • Staphylococcus aureus
  • Staphylococcal Infections
  • Prospective Studies
  • Penicillins
  • Middle Aged
  • Microbiology
  • Metabolic Clearance Rate
  • Male