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LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development.

Publication ,  Journal Article
Gong, Y; Slee, RB; Fukai, N; Rawadi, G; Roman-Roman, S; Reginato, AM; Wang, H; Cundy, T; Glorieux, FH; Lev, D; Zacharin, M; Oexle, K; Apte, S ...
Published in: Cell
November 16, 2001

In humans, low peak bone mass is a significant risk factor for osteoporosis. We report that LRP5, encoding the low-density lipoprotein receptor-related protein 5, affects bone mass accrual during growth. Mutations in LRP5 cause the autosomal recessive disorder osteoporosis-pseudoglioma syndrome (OPPG). We find that OPPG carriers have reduced bone mass when compared to age- and gender-matched controls. We demonstrate LRP5 expression by osteoblasts in situ and show that LRP5 can transduce Wnt signaling in vitro via the canonical pathway. We further show that a mutant-secreted form of LRP5 can reduce bone thickness in mouse calvarial explant cultures. These data indicate that Wnt-mediated signaling via LRP5 affects bone accrual during growth and is important for the establishment of peak bone mass.

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Published In

Cell

DOI

ISSN

0092-8674

Publication Date

November 16, 2001

Volume

107

Issue

4

Start / End Page

513 / 523

Location

United States

Related Subject Headings

  • Zebrafish Proteins
  • Wnt4 Protein
  • Wnt3 Protein
  • Wnt2 Protein
  • Wnt-5a Protein
  • Wnt Proteins
  • Transforming Growth Factor beta
  • Transfection
  • Syndrome
  • Stromal Cells
 

Citation

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Gong, Y., Slee, R. B., Fukai, N., Rawadi, G., Roman-Roman, S., Reginato, A. M., … Osteoporosis-Pseudoglioma Syndrome Collaborative Group, . (2001). LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. Cell, 107(4), 513–523. https://doi.org/10.1016/s0092-8674(01)00571-2
Gong, Y., R. B. Slee, N. Fukai, G. Rawadi, S. Roman-Roman, A. M. Reginato, H. Wang, et al. “LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development.Cell 107, no. 4 (November 16, 2001): 513–23. https://doi.org/10.1016/s0092-8674(01)00571-2.
Gong Y, Slee RB, Fukai N, Rawadi G, Roman-Roman S, Reginato AM, et al. LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. Cell. 2001 Nov 16;107(4):513–23.
Gong, Y., et al. “LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development.Cell, vol. 107, no. 4, Nov. 2001, pp. 513–23. Pubmed, doi:10.1016/s0092-8674(01)00571-2.
Gong Y, Slee RB, Fukai N, Rawadi G, Roman-Roman S, Reginato AM, Wang H, Cundy T, Glorieux FH, Lev D, Zacharin M, Oexle K, Marcelino J, Suwairi W, Heeger S, Sabatakos G, Apte S, Adkins WN, Allgrove J, Arslan-Kirchner M, Batch JA, Beighton P, Black GC, Boles RG, Boon LM, Borrone C, Brunner HG, Carle GF, Dallapiccola B, De Paepe A, Floege B, Halfhide ML, Hall B, Hennekam RC, Hirose T, Jans A, Jüppner H, Kim CA, Keppler-Noreuil K, Kohlschuetter A, LaCombe D, Lambert M, Lemyre E, Letteboer T, Peltonen L, Ramesar RS, Romanengo M, Somer H, Steichen-Gersdorf E, Steinmann B, Sullivan B, Superti-Furga A, Swoboda W, van den Boogaard MJ, Van Hul W, Vikkula M, Votruba M, Zabel B, Garcia T, Baron R, Olsen BR, Warman ML, Osteoporosis-Pseudoglioma Syndrome Collaborative Group. LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. Cell. 2001 Nov 16;107(4):513–523.
Journal cover image

Published In

Cell

DOI

ISSN

0092-8674

Publication Date

November 16, 2001

Volume

107

Issue

4

Start / End Page

513 / 523

Location

United States

Related Subject Headings

  • Zebrafish Proteins
  • Wnt4 Protein
  • Wnt3 Protein
  • Wnt2 Protein
  • Wnt-5a Protein
  • Wnt Proteins
  • Transforming Growth Factor beta
  • Transfection
  • Syndrome
  • Stromal Cells