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Viruses in the treatment of brain tumors.

Publication ,  Journal Article
Fecci, PE; Gromeier, M; Sampson, JH
Published in: Neuroimaging Clin N Am
November 2002

The grave outlook for malignant glioma patients in spite of improvements to current modalities has ushered in new approaches to therapy. Viruses have emerged on the scene and gained attention for their ability to play essentially two roles: first, as vectors for therapeutic gene delivery and second, as engineered infectious agents capable of selectively lysing tumor cells. To date, clinical brain tumor trials using viruses for gene delivery have employed retroviral or adenoviral vectors to introduce ganciclovir susceptibility to tumors in the form of the HSV1-TK gene. Clinical oncolytic studies, on the other hand, have evaluated a conditionally replicating HSV as an antineoplastic agent. Despite some promise afforded by these trials, further studies are warranted; the investigation of additional viruses to play these roles is inevitable and is now precedented.

Duke Scholars

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Published In

Neuroimaging Clin N Am

DOI

ISSN

1052-5149

Publication Date

November 2002

Volume

12

Issue

4

Start / End Page

553 / 570

Location

United States

Related Subject Headings

  • Virus Replication
  • Thymidine Kinase
  • Retroviridae
  • Nuclear Medicine & Medical Imaging
  • Mutation
  • Magnetic Resonance Imaging
  • Humans
  • Herpesvirus 1, Human
  • Glioma
  • Genetic Vectors
 

Citation

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ICMJE
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Fecci, P. E., Gromeier, M., & Sampson, J. H. (2002). Viruses in the treatment of brain tumors. Neuroimaging Clin N Am, 12(4), 553–570. https://doi.org/10.1016/s1052-5149(02)00028-x
Fecci, Peter E., Matthias Gromeier, and John H. Sampson. “Viruses in the treatment of brain tumors.Neuroimaging Clin N Am 12, no. 4 (November 2002): 553–70. https://doi.org/10.1016/s1052-5149(02)00028-x.
Fecci PE, Gromeier M, Sampson JH. Viruses in the treatment of brain tumors. Neuroimaging Clin N Am. 2002 Nov;12(4):553–70.
Fecci, Peter E., et al. “Viruses in the treatment of brain tumors.Neuroimaging Clin N Am, vol. 12, no. 4, Nov. 2002, pp. 553–70. Pubmed, doi:10.1016/s1052-5149(02)00028-x.
Fecci PE, Gromeier M, Sampson JH. Viruses in the treatment of brain tumors. Neuroimaging Clin N Am. 2002 Nov;12(4):553–570.
Journal cover image

Published In

Neuroimaging Clin N Am

DOI

ISSN

1052-5149

Publication Date

November 2002

Volume

12

Issue

4

Start / End Page

553 / 570

Location

United States

Related Subject Headings

  • Virus Replication
  • Thymidine Kinase
  • Retroviridae
  • Nuclear Medicine & Medical Imaging
  • Mutation
  • Magnetic Resonance Imaging
  • Humans
  • Herpesvirus 1, Human
  • Glioma
  • Genetic Vectors