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Animal models of bleeding and tissue repair.

Publication ,  Journal Article
Hoffman, M
Published in: Haemophilia
July 2008

While a number of animal models have been developed for human haemophilia, it has been difficult to develop reproducible measures of bleeding in these models. They have also not been extensively utilized to study the complications of haemophilia beyond blood loss. Poor haemostatic function also leads to local haematomas, joint damage and poor wound healing. Some of the abnormalities related to bleeding are because of the deleterious effects of iron deposition in the tissues. Evidence from mouse skin wound and joint haemorrhage models suggests that bleeding and iron deposition initiate a vicious cycle of inflammation, angiogenesis and renewed bleeding. However, there is much yet to be learned about the effects of bleeding on tissue responses, including validating the results of animal studies in clinical trials.

Duke Scholars

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Published In

Haemophilia

DOI

EISSN

1365-2516

Publication Date

July 2008

Volume

14 Suppl 3

Start / End Page

62 / 67

Location

England

Related Subject Headings

  • Wound Healing
  • Reproducibility of Results
  • Rabbits
  • Neovascularization, Physiologic
  • Mice
  • Humans
  • Hemorrhage
  • Hemophilia A
  • Granulation Tissue
  • Exudates and Transudates
 

Citation

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Hoffman, M. (2008). Animal models of bleeding and tissue repair. Haemophilia, 14 Suppl 3, 62–67. https://doi.org/10.1111/j.1365-2516.2008.01729.x
Hoffman, M. “Animal models of bleeding and tissue repair.Haemophilia 14 Suppl 3 (July 2008): 62–67. https://doi.org/10.1111/j.1365-2516.2008.01729.x.
Hoffman M. Animal models of bleeding and tissue repair. Haemophilia. 2008 Jul;14 Suppl 3:62–7.
Hoffman, M. “Animal models of bleeding and tissue repair.Haemophilia, vol. 14 Suppl 3, July 2008, pp. 62–67. Pubmed, doi:10.1111/j.1365-2516.2008.01729.x.
Hoffman M. Animal models of bleeding and tissue repair. Haemophilia. 2008 Jul;14 Suppl 3:62–67.
Journal cover image

Published In

Haemophilia

DOI

EISSN

1365-2516

Publication Date

July 2008

Volume

14 Suppl 3

Start / End Page

62 / 67

Location

England

Related Subject Headings

  • Wound Healing
  • Reproducibility of Results
  • Rabbits
  • Neovascularization, Physiologic
  • Mice
  • Humans
  • Hemorrhage
  • Hemophilia A
  • Granulation Tissue
  • Exudates and Transudates