Scholars@Duke publication: Psychotropic actions of BW 234U in the treatment of inpatient schizophrenics: A dose‐range study

Psychotropic actions of BW 234U in the treatment of inpatient schizophrenics: A dose‐range study

Publication , Journal Article

Guy, W; Manov, G; Wilson, WH; Ban, TA; Fjetland, OK; Manberg, PJ; Dren, AT

Published in: Drug Development Research

January 1, 1983

In a 28‐day, dose‐range study, 11 chronic schizophrenic inpatients newly admitted to the hospital with acute exacerbations were administered a new antipsychotic, BW 234U, in daily doses ranging from 100 to 400 mg/day on a fixed/flexible schedule to determine therapeutic dose range, safety, and psychotropic activity with special regard to possible antiaggressive action. The results of weekly assessments with standard psychiatric rating instruments indicate that BW 234U has dual psychotropic action—an antipsychotic and an activating effect—that may have potential value in the treatment of depressive illness. The drug appears to be relatively free from neurologic, cardiovascular, anticholinergic, and CNS‐depressant side effects. Copyright © 1983 Alan R. Liss, Inc.

Duke Scholars

Author William Herman Wilson Psychiatry & Behavioral Sciences, Behavioral Medicine & Neur ...

Author Anthony Thomas Dren School of Nursing

Published In

Drug Development Research

DOI

10.1002/ddr.430030306

EISSN

1098-2299

ISSN

0272-4391

Publication Date

January 1, 1983

Volume

Issue

Start / End Page

245 / 252

Related Subject Headings

Pharmacology & Pharmacy
1115 Pharmacology and Pharmaceutical Sciences

Citation

APA

Chicago

ICMJE

MLA

NLM

Guy, W., Manov, G., Wilson, W. H., Ban, T. A., Fjetland, O. K., Manberg, P. J., & Dren, A. T. (1983). Psychotropic actions of BW 234U in the treatment of inpatient schizophrenics: A dose‐range study. Drug Development Research, 3(3), 245–252. https://doi.org/10.1002/ddr.430030306

Guy, W., G. Manov, W. H. Wilson, T. A. Ban, O. K. Fjetland, P. J. Manberg, and A. T. Dren. “Psychotropic actions of BW 234U in the treatment of inpatient schizophrenics: A dose‐range study.” Drug Development Research 3, no. 3 (January 1, 1983): 245–52. https://doi.org/10.1002/ddr.430030306.

Guy W, Manov G, Wilson WH, Ban TA, Fjetland OK, Manberg PJ, et al. Psychotropic actions of BW 234U in the treatment of inpatient schizophrenics: A dose‐range study. Drug Development Research. 1983 Jan 1;3(3):245–52.

Guy, W., et al. “Psychotropic actions of BW 234U in the treatment of inpatient schizophrenics: A dose‐range study.” Drug Development Research, vol. 3, no. 3, Jan. 1983, pp. 245–52. Scopus, doi:10.1002/ddr.430030306.

Guy W, Manov G, Wilson WH, Ban TA, Fjetland OK, Manberg PJ, Dren AT. Psychotropic actions of BW 234U in the treatment of inpatient schizophrenics: A dose‐range study. Drug Development Research. 1983 Jan 1;3(3):245–252.

Published In

Drug Development Research

DOI

10.1002/ddr.430030306

EISSN

1098-2299

ISSN

0272-4391

Publication Date

January 1, 1983

Volume

Issue

Start / End Page

245 / 252

Related Subject Headings

Pharmacology & Pharmacy
1115 Pharmacology and Pharmaceutical Sciences