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Genetic regulation of pristane-induced oil granuloma responses.

Publication ,  Journal Article
Chen, H; Liao, D; Holl, TM; Snowden, P; Ueda, Y; Kelsoe, G
Published in: Int J Exp Pathol
October 2010

Oil granuloma (OG) induced by intraperitoneal injection of pristane represents a non-infectious granuloma. Oil granuloma has been characterized, but the regulation of its formation still remains unknown. To address this, we injected pristane into various mice deficient for genes including, linker for activation of T cells (LAT), μMT, LTα, TNFα, IL-6. T cell deficient mice (LAT(-/-) ) responded to pristane by developing serosal granuloma and mesenteric granuloma (MG) as in wild type mice. The absence of B cells blocked serosal granuloma (SG) formation and diminished MG development in response to pristane. However, even when a comparable number of B cells were present in the mesentery, the absence of TNFα resulted in similar defects in OG formation after pristane treatment, demonstrating that both B cells and TNFα are very crucial for pristane-induced OG formation. Interestingly, IL-6(-/-) mice had intact MG formation; however, SG organization was impaired. These studies provide insight into granulomateous pathology induced by non-infectious substances for example, biomedical sutures.

Duke Scholars

Published In

Int J Exp Pathol

DOI

EISSN

1365-2613

Publication Date

October 2010

Volume

91

Issue

5

Start / End Page

472 / 483

Location

England

Related Subject Headings

  • Tumor Necrosis Factor-alpha
  • Terpenes
  • Phosphoproteins
  • Pathology
  • Mice, Mutant Strains
  • Mice, Inbred C57BL
  • Mice
  • Membrane Proteins
  • Male
  • Lymphotoxin-alpha
 

Citation

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Chen, H., Liao, D., Holl, T. M., Snowden, P., Ueda, Y., & Kelsoe, G. (2010). Genetic regulation of pristane-induced oil granuloma responses. Int J Exp Pathol, 91(5), 472–483. https://doi.org/10.1111/j.1365-2613.2010.00732.x
Chen, Huaiyong, Dongmei Liao, T Matt Holl, Pilar Snowden, Yoshihiro Ueda, and Garnett Kelsoe. “Genetic regulation of pristane-induced oil granuloma responses.Int J Exp Pathol 91, no. 5 (October 2010): 472–83. https://doi.org/10.1111/j.1365-2613.2010.00732.x.
Chen H, Liao D, Holl TM, Snowden P, Ueda Y, Kelsoe G. Genetic regulation of pristane-induced oil granuloma responses. Int J Exp Pathol. 2010 Oct;91(5):472–83.
Chen, Huaiyong, et al. “Genetic regulation of pristane-induced oil granuloma responses.Int J Exp Pathol, vol. 91, no. 5, Oct. 2010, pp. 472–83. Pubmed, doi:10.1111/j.1365-2613.2010.00732.x.
Chen H, Liao D, Holl TM, Snowden P, Ueda Y, Kelsoe G. Genetic regulation of pristane-induced oil granuloma responses. Int J Exp Pathol. 2010 Oct;91(5):472–483.
Journal cover image

Published In

Int J Exp Pathol

DOI

EISSN

1365-2613

Publication Date

October 2010

Volume

91

Issue

5

Start / End Page

472 / 483

Location

England

Related Subject Headings

  • Tumor Necrosis Factor-alpha
  • Terpenes
  • Phosphoproteins
  • Pathology
  • Mice, Mutant Strains
  • Mice, Inbred C57BL
  • Mice
  • Membrane Proteins
  • Male
  • Lymphotoxin-alpha