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PGC-1α, a potential therapeutic target for early intervention in Parkinson's disease.

Publication ,  Journal Article
Zheng, B; Liao, Z; Locascio, JJ; Lesniak, KA; Roderick, SS; Watt, ML; Eklund, AC; Zhang-James, Y; Kim, PD; Hauser, MA; Grünblatt, E; Moran, LB ...
Published in: Sci Transl Med
October 6, 2010

Parkinson's disease affects 5 million people worldwide, but the molecular mechanisms underlying its pathogenesis are still unclear. Here, we report a genome-wide meta-analysis of gene sets (groups of genes that encode the same biological pathway or process) in 410 samples from patients with symptomatic Parkinson's and subclinical disease and healthy controls. We analyzed 6.8 million raw data points from nine genome-wide expression studies, and 185 laser-captured human dopaminergic neuron and substantia nigra transcriptomes, followed by two-stage replication on three platforms. We found 10 gene sets with previously unknown associations with Parkinson's disease. These gene sets pinpoint defects in mitochondrial electron transport, glucose utilization, and glucose sensing and reveal that they occur early in disease pathogenesis. Genes controlling cellular bioenergetics that are expressed in response to peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) are underexpressed in Parkinson's disease patients. Activation of PGC-1α results in increased expression of nuclear-encoded subunits of the mitochondrial respiratory chain and blocks the dopaminergic neuron loss induced by mutant α-synuclein or the pesticide rotenone in cellular disease models. Our systems biology analysis of Parkinson's disease identifies PGC-1α as a potential therapeutic target for early intervention.

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Published In

Sci Transl Med

DOI

EISSN

1946-6242

Publication Date

October 6, 2010

Volume

2

Issue

52

Start / End Page

52ra73

Location

United States

Related Subject Headings

  • alpha-Synuclein
  • Transcription Factors
  • Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
  • Parkinson Disease
  • Neurons
  • Middle Aged
  • Male
  • Humans
  • Heat-Shock Proteins
  • Genome-Wide Association Study
 

Citation

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Zheng, B., Liao, Z., Locascio, J. J., Lesniak, K. A., Roderick, S. S., Watt, M. L., … Global PD Gene Expression (GPEX) Consortium. (2010). PGC-1α, a potential therapeutic target for early intervention in Parkinson's disease. Sci Transl Med, 2(52), 52ra73. https://doi.org/10.1126/scitranslmed.3001059
Zheng, Bin, Zhixiang Liao, Joseph J. Locascio, Kristen A. Lesniak, Sarah S. Roderick, Marla L. Watt, Aron C. Eklund, et al. “PGC-1α, a potential therapeutic target for early intervention in Parkinson's disease.Sci Transl Med 2, no. 52 (October 6, 2010): 52ra73. https://doi.org/10.1126/scitranslmed.3001059.
Zheng B, Liao Z, Locascio JJ, Lesniak KA, Roderick SS, Watt ML, et al. PGC-1α, a potential therapeutic target for early intervention in Parkinson's disease. Sci Transl Med. 2010 Oct 6;2(52):52ra73.
Zheng, Bin, et al. “PGC-1α, a potential therapeutic target for early intervention in Parkinson's disease.Sci Transl Med, vol. 2, no. 52, Oct. 2010, p. 52ra73. Pubmed, doi:10.1126/scitranslmed.3001059.
Zheng B, Liao Z, Locascio JJ, Lesniak KA, Roderick SS, Watt ML, Eklund AC, Zhang-James Y, Kim PD, Hauser MA, Grünblatt E, Moran LB, Mandel SA, Riederer P, Miller RM, Federoff HJ, Wüllner U, Papapetropoulos S, Youdim MB, Cantuti-Castelvetri I, Young AB, Vance JM, Davis RL, Hedreen JC, Adler CH, Beach TG, Graeber MB, Middleton FA, Rochet J-C, Scherzer CR, Global PD Gene Expression (GPEX) Consortium. PGC-1α, a potential therapeutic target for early intervention in Parkinson's disease. Sci Transl Med. 2010 Oct 6;2(52):52ra73.

Published In

Sci Transl Med

DOI

EISSN

1946-6242

Publication Date

October 6, 2010

Volume

2

Issue

52

Start / End Page

52ra73

Location

United States

Related Subject Headings

  • alpha-Synuclein
  • Transcription Factors
  • Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
  • Parkinson Disease
  • Neurons
  • Middle Aged
  • Male
  • Humans
  • Heat-Shock Proteins
  • Genome-Wide Association Study