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Persistent eosinophilia and Strongyloides infection in Montagnard refugees after presumptive albendazole therapy.

Publication ,  Journal Article
Goswami, ND; Shah, JJ; Corey, GR; Stout, JE
Published in: Am J Trop Med Hyg
August 2009

Chronic helminth infections are common in refugee populations and may persist years after immigration. Asymptomatic Strongyloides stercoralis infection raises particular concern because of its potential for complications in immunosuppressed patients. We examined 172 Montagnard refugees resettled to Wake County, North Carolina from 2002 through 2003. Refugees were pretreated with albendazole for five days and screened for health conditions after arrival. Eosinophilia was present in 41 of 171 refugees at the first blood draw. Only 1 of 172 had a stool helminth (Fasciola) identified by microscopy. On repeat testing, 13 people had persistent eosinophilia. Results of serologic analysis for Strongyloides were available in 24 persons. Eosinophil counts decreased significantly after treatment with ivermectin in nine refugees (P = 0.039). Persistent eosinophilia, likely caused by Strongyloides infection, was common in this cohort of Montagnard refugees. Clinicians should understand the limitations of stool microscopy in diagnosis of strongyloidiasis, the limited effectiveness of albendazole in treating strongyloidiasis, and the importance of following-up refugees with persistent eosinophilia.

Duke Scholars

Published In

Am J Trop Med Hyg

EISSN

1476-1645

Publication Date

August 2009

Volume

81

Issue

2

Start / End Page

302 / 304

Location

United States

Related Subject Headings

  • Vietnam
  • Tropical Medicine
  • Treatment Failure
  • Strongyloidiasis
  • Strongyloides
  • Refugees
  • North Carolina
  • Ivermectin
  • Humans
  • Eosinophilia
 

Citation

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Goswami, N. D., Shah, J. J., Corey, G. R., & Stout, J. E. (2009). Persistent eosinophilia and Strongyloides infection in Montagnard refugees after presumptive albendazole therapy. Am J Trop Med Hyg, 81(2), 302–304.
Goswami, Neela D., J Jina Shah, G Ralph Corey, and Jason E. Stout. “Persistent eosinophilia and Strongyloides infection in Montagnard refugees after presumptive albendazole therapy.Am J Trop Med Hyg 81, no. 2 (August 2009): 302–4.
Goswami ND, Shah JJ, Corey GR, Stout JE. Persistent eosinophilia and Strongyloides infection in Montagnard refugees after presumptive albendazole therapy. Am J Trop Med Hyg. 2009 Aug;81(2):302–4.
Goswami, Neela D., et al. “Persistent eosinophilia and Strongyloides infection in Montagnard refugees after presumptive albendazole therapy.Am J Trop Med Hyg, vol. 81, no. 2, Aug. 2009, pp. 302–04.
Goswami ND, Shah JJ, Corey GR, Stout JE. Persistent eosinophilia and Strongyloides infection in Montagnard refugees after presumptive albendazole therapy. Am J Trop Med Hyg. 2009 Aug;81(2):302–304.

Published In

Am J Trop Med Hyg

EISSN

1476-1645

Publication Date

August 2009

Volume

81

Issue

2

Start / End Page

302 / 304

Location

United States

Related Subject Headings

  • Vietnam
  • Tropical Medicine
  • Treatment Failure
  • Strongyloidiasis
  • Strongyloides
  • Refugees
  • North Carolina
  • Ivermectin
  • Humans
  • Eosinophilia