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T-bet-dependent expression of osteopontin contributes to T cell polarization.

Publication ,  Journal Article
Shinohara, ML; Jansson, M; Hwang, ES; Werneck, MBF; Glimcher, LH; Cantor, H
Published in: Proc Natl Acad Sci U S A
November 22, 2005

The osteopontin (Opn) glycoprotein has been implicated in diverse physiological processes, including vascularization, bone formation, and inflammatory responses. Studies of its role in immune responses has suggested that Opn can set the early stage of type-1 immune (cell-mediated) responses through differential regulation of IL-12 and IL-10 cytokine gene expression in macrophages. Although Opn has been suggested to play a role in the development of type-1 immunity, little is known about control of Opn gene expression. Here, we report that Opn gene expression in activated T cells, but not macrophages, is regulated by T-bet, a transcription factor that controls CD4+ T helper (Th1) cell lineage commitment. We also find that T-bet-dependent expression of Opn in T cells is essential for efficient skewing of CD4+ T and CD8+ T cells toward the Th1 and type 1 CD8+ T cells (Tc1) pathway, respectively. Taken together, these findings begin to delineate the genetic basis of Opn expression in T cells and further clarify the role of Opn in Th and Tc1 development.

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Published In

Proc Natl Acad Sci U S A

DOI

ISSN

0027-8424

Publication Date

November 22, 2005

Volume

102

Issue

47

Start / End Page

17101 / 17106

Location

United States

Related Subject Headings

  • Transcription Factors
  • Th1 Cells
  • T-Lymphocyte Subsets
  • T-Box Domain Proteins
  • Sialoglycoproteins
  • Osteopontin
  • Molecular Sequence Data
  • Mice, Transgenic
  • Mice, Knockout
  • Mice, Inbred C57BL
 

Citation

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Shinohara, M. L., Jansson, M., Hwang, E. S., Werneck, M. B. F., Glimcher, L. H., & Cantor, H. (2005). T-bet-dependent expression of osteopontin contributes to T cell polarization. Proc Natl Acad Sci U S A, 102(47), 17101–17106. https://doi.org/10.1073/pnas.0508666102
Shinohara, Mari L., Marianne Jansson, Eun Sook Hwang, Miriam B. F. Werneck, Laurie H. Glimcher, and Harvey Cantor. “T-bet-dependent expression of osteopontin contributes to T cell polarization.Proc Natl Acad Sci U S A 102, no. 47 (November 22, 2005): 17101–6. https://doi.org/10.1073/pnas.0508666102.
Shinohara ML, Jansson M, Hwang ES, Werneck MBF, Glimcher LH, Cantor H. T-bet-dependent expression of osteopontin contributes to T cell polarization. Proc Natl Acad Sci U S A. 2005 Nov 22;102(47):17101–6.
Shinohara, Mari L., et al. “T-bet-dependent expression of osteopontin contributes to T cell polarization.Proc Natl Acad Sci U S A, vol. 102, no. 47, Nov. 2005, pp. 17101–06. Pubmed, doi:10.1073/pnas.0508666102.
Shinohara ML, Jansson M, Hwang ES, Werneck MBF, Glimcher LH, Cantor H. T-bet-dependent expression of osteopontin contributes to T cell polarization. Proc Natl Acad Sci U S A. 2005 Nov 22;102(47):17101–17106.
Journal cover image

Published In

Proc Natl Acad Sci U S A

DOI

ISSN

0027-8424

Publication Date

November 22, 2005

Volume

102

Issue

47

Start / End Page

17101 / 17106

Location

United States

Related Subject Headings

  • Transcription Factors
  • Th1 Cells
  • T-Lymphocyte Subsets
  • T-Box Domain Proteins
  • Sialoglycoproteins
  • Osteopontin
  • Molecular Sequence Data
  • Mice, Transgenic
  • Mice, Knockout
  • Mice, Inbred C57BL