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The use of nalmefene for intrathecal opioid-associated nausea in postpartum patients.

Publication ,  Journal Article
Ward, RC; Lawrence, RL; Hawkins, RJ; DiChiara, SE; Biegner, AR; Vacchiano, CA
Published in: AANA journal
February 2002

The aim of this study was to compare the severity of nausea and incidence of emesis in laboring parturients who received intravenous nalmefene or placebo following an intrathecal opioid (ITO). We randomly assigned 60 ASA class I or II multiparous women to receive nalmefene or placebo. Subjects received fentanyl, 25 micrograms, and morphine, 250 micrograms, intrathecally on request for analgesia. Thirty minutes after vaginal delivery, the experimental group received nalmefene, 20 micrograms, and the placebo group received an equivalent volume of normal saline intravenously. Visual analog scale nausea scores and data about episodes of emesis were obtained during labor and during the first 24 hours postpartum. There were no significant differences in age, weight, duration of labor, volume of intravenous fluids infused, time from last meal to delivery, or time from administration of the ITO to injection of the study drug. There were no significant differences in mean visual analog scale nausea scores or frequency of emesis for any time interval. Nalmefene, 20 micrograms, given intravenously within 30 minutes of vaginal delivery does not significantly reduce the nausea and vomiting associated with the use of ITOs for labor analgesia.

Duke Scholars

Published In

AANA journal

EISSN

2162-5239

ISSN

0094-6354

Publication Date

February 2002

Volume

70

Issue

1

Start / End Page

57 / 60

Related Subject Headings

  • Postpartum Period
  • Postoperative Nausea and Vomiting
  • Narcotic Antagonists
  • Naltrexone
  • Injections, Spinal
  • Humans
  • Female
  • Double-Blind Method
  • Anesthesiology
  • Analgesics, Opioid
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Ward, R. C., Lawrence, R. L., Hawkins, R. J., DiChiara, S. E., Biegner, A. R., & Vacchiano, C. A. (2002). The use of nalmefene for intrathecal opioid-associated nausea in postpartum patients. AANA Journal, 70(1), 57–60.
Ward, Robyn C., Robert L. Lawrence, Robert J. Hawkins, Steven E. DiChiara, Andrew R. Biegner, and Charles A. Vacchiano. “The use of nalmefene for intrathecal opioid-associated nausea in postpartum patients.AANA Journal 70, no. 1 (February 2002): 57–60.
Ward RC, Lawrence RL, Hawkins RJ, DiChiara SE, Biegner AR, Vacchiano CA. The use of nalmefene for intrathecal opioid-associated nausea in postpartum patients. AANA journal. 2002 Feb;70(1):57–60.
Ward, Robyn C., et al. “The use of nalmefene for intrathecal opioid-associated nausea in postpartum patients.AANA Journal, vol. 70, no. 1, Feb. 2002, pp. 57–60.
Ward RC, Lawrence RL, Hawkins RJ, DiChiara SE, Biegner AR, Vacchiano CA. The use of nalmefene for intrathecal opioid-associated nausea in postpartum patients. AANA journal. 2002 Feb;70(1):57–60.

Published In

AANA journal

EISSN

2162-5239

ISSN

0094-6354

Publication Date

February 2002

Volume

70

Issue

1

Start / End Page

57 / 60

Related Subject Headings

  • Postpartum Period
  • Postoperative Nausea and Vomiting
  • Narcotic Antagonists
  • Naltrexone
  • Injections, Spinal
  • Humans
  • Female
  • Double-Blind Method
  • Anesthesiology
  • Analgesics, Opioid