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Acute time to response in the Treatment for Adolescents with Depression Study (TADS).

Publication ,  Journal Article
Kratochvil, C; Emslie, G; Silva, S; McNulty, S; Walkup, J; Curry, J; Reinecke, M; Vitiello, B; Rohde, P; Feeny, N; Casat, C; Pathak, S ...
Published in: J Am Acad Child Adolesc Psychiatry
December 2006

OBJECTIVE: To examine the time to response for both pharmacotherapy and psychotherapy in the Treatment for Adolescents with Depression Study (TADS). METHOD: Adolescents (N = 439, ages 12 to 17 years) with major depressive disorder were randomized to fluoxetine (FLX), cognitive-behavioral therapy (CBT), their combination (COMB), or pill placebo (PBO). Defining response as very much improved or much improved on the Clinical Global Impression-Improvement Scale (CGI-I), survival analyses using Cox proportional hazards models, and Kaplan-Meier curves were conducted to evaluate time to first response and time to stable response for subjects receiving pharmacotherapy (COMB, FLX, PBO) as well as for subjects receiving CBT (COMB, CBT). Direct comparisons between pharmacotherapy and CBT were not made because of differences in visit schedules. RESULTS: Based on pharmacotherapist CGI-I scores, COMB and FLX showed faster onset of benefit than PBO on time to response and time to stable response (p < .001), and COMB was faster than FLX on time to stable response (p = .034). The probability of sustained early response was approximately threefold greater for COMB than PBO, twofold greater for FLX than PBO, and 1.5-fold greater for COMB than FLX. On the psychotherapist CGI-I scores, both first response and stable response occurred faster in COMB than CBT (p < .001), with a probability of sustained early response approximately threefold greater for COMB than CBT. CONCLUSIONS: In the acute treatment of depressed adolescents, FLX and COMB accelerate response relative to PBO, and COMB accelerates response relative to CBT alone.

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Published In

J Am Acad Child Adolesc Psychiatry

DOI

ISSN

0890-8567

Publication Date

December 2006

Volume

45

Issue

12

Start / End Page

1412 / 1418

Location

United States

Related Subject Headings

  • Time Factors
  • Surveys and Questionnaires
  • Selective Serotonin Reuptake Inhibitors
  • Male
  • Humans
  • Fluoxetine
  • Female
  • Developmental & Child Psychology
  • Depressive Disorder, Major
  • Combined Modality Therapy
 

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Kratochvil, C., Emslie, G., Silva, S., McNulty, S., Walkup, J., Curry, J., … TADS Team. (2006). Acute time to response in the Treatment for Adolescents with Depression Study (TADS). J Am Acad Child Adolesc Psychiatry, 45(12), 1412–1418. https://doi.org/10.1097/01.chi.0000237710.73755.14
Kratochvil, Christopher, Graham Emslie, Susan Silva, Steve McNulty, John Walkup, John Curry, Mark Reinecke, et al. “Acute time to response in the Treatment for Adolescents with Depression Study (TADS).J Am Acad Child Adolesc Psychiatry 45, no. 12 (December 2006): 1412–18. https://doi.org/10.1097/01.chi.0000237710.73755.14.
Kratochvil C, Emslie G, Silva S, McNulty S, Walkup J, Curry J, et al. Acute time to response in the Treatment for Adolescents with Depression Study (TADS). J Am Acad Child Adolesc Psychiatry. 2006 Dec;45(12):1412–8.
Kratochvil, Christopher, et al. “Acute time to response in the Treatment for Adolescents with Depression Study (TADS).J Am Acad Child Adolesc Psychiatry, vol. 45, no. 12, Dec. 2006, pp. 1412–18. Pubmed, doi:10.1097/01.chi.0000237710.73755.14.
Kratochvil C, Emslie G, Silva S, McNulty S, Walkup J, Curry J, Reinecke M, Vitiello B, Rohde P, Feeny N, Casat C, Pathak S, Weller E, May D, Mayes T, Robins M, March J, TADS Team. Acute time to response in the Treatment for Adolescents with Depression Study (TADS). J Am Acad Child Adolesc Psychiatry. 2006 Dec;45(12):1412–1418.
Journal cover image

Published In

J Am Acad Child Adolesc Psychiatry

DOI

ISSN

0890-8567

Publication Date

December 2006

Volume

45

Issue

12

Start / End Page

1412 / 1418

Location

United States

Related Subject Headings

  • Time Factors
  • Surveys and Questionnaires
  • Selective Serotonin Reuptake Inhibitors
  • Male
  • Humans
  • Fluoxetine
  • Female
  • Developmental & Child Psychology
  • Depressive Disorder, Major
  • Combined Modality Therapy