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Impact of stressful life events, depression, social support, coping, and cortisol on progression to AIDS.

Publication ,  Journal Article
Leserman, J; Petitto, JM; Golden, RN; Gaynes, BN; Gu, H; Perkins, DO; Silva, SG; Folds, JD; Evans, DL
Published in: The American journal of psychiatry
August 2000

This study examined prospectively the effects of stressful events, depressive symptoms, social support, coping methods, and cortisol levels on progression of HIV-1 infection.Eighty-two homosexual men with HIV type-1 infection without AIDS or symptoms at baseline were studied every 6 months for up to 7. 5 years. Men were recruited from rural and urban areas in North Carolina, and none was using antiretroviral medications at entry. Disease progression was defined as CD4(+) lymphocyte count <200/microl or the presence of an AIDS indicator condition.Cox regression models with time-dependent covariates were used adjusting for race, baseline CD4(+) count and viral load, and cumulative average antiretroviral medications. Faster progression to AIDS was associated with higher cumulative average stressful life events, coping by means of denial, and higher serum cortisol as well as with lower cumulative average satisfaction with social support. Other background (e.g., age, education) and health habit variables (e.g., tobacco use, risky sexual behavior) did not significantly predict disease progression. The risk of AIDS was approximately doubled for every 1.5-unit decrease in cumulative average support satisfaction and for every cumulative average increase of one severe stressor, one unit of denial, and 5 mg/dl of cortisol.Further research is needed to determine if treatments based on these findings might alter the clinical course of HIV-1 infection.

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Published In

The American journal of psychiatry

DOI

EISSN

1535-7228

ISSN

0002-953X

Publication Date

August 2000

Volume

157

Issue

8

Start / End Page

1221 / 1228

Related Subject Headings

  • Survival Analysis
  • Social Support
  • Psychiatry
  • Prospective Studies
  • Middle Aged
  • Male
  • Life Change Events
  • Immunity, Cellular
  • Hydrocortisone
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Leserman, J., Petitto, J. M., Golden, R. N., Gaynes, B. N., Gu, H., Perkins, D. O., … Evans, D. L. (2000). Impact of stressful life events, depression, social support, coping, and cortisol on progression to AIDS. The American Journal of Psychiatry, 157(8), 1221–1228. https://doi.org/10.1176/appi.ajp.157.8.1221
Leserman, J., J. M. Petitto, R. N. Golden, B. N. Gaynes, H. Gu, D. O. Perkins, S. G. Silva, J. D. Folds, and D. L. Evans. “Impact of stressful life events, depression, social support, coping, and cortisol on progression to AIDS.The American Journal of Psychiatry 157, no. 8 (August 2000): 1221–28. https://doi.org/10.1176/appi.ajp.157.8.1221.
Leserman J, Petitto JM, Golden RN, Gaynes BN, Gu H, Perkins DO, et al. Impact of stressful life events, depression, social support, coping, and cortisol on progression to AIDS. The American journal of psychiatry. 2000 Aug;157(8):1221–8.
Leserman, J., et al. “Impact of stressful life events, depression, social support, coping, and cortisol on progression to AIDS.The American Journal of Psychiatry, vol. 157, no. 8, Aug. 2000, pp. 1221–28. Epmc, doi:10.1176/appi.ajp.157.8.1221.
Leserman J, Petitto JM, Golden RN, Gaynes BN, Gu H, Perkins DO, Silva SG, Folds JD, Evans DL. Impact of stressful life events, depression, social support, coping, and cortisol on progression to AIDS. The American journal of psychiatry. 2000 Aug;157(8):1221–1228.
Journal cover image

Published In

The American journal of psychiatry

DOI

EISSN

1535-7228

ISSN

0002-953X

Publication Date

August 2000

Volume

157

Issue

8

Start / End Page

1221 / 1228

Related Subject Headings

  • Survival Analysis
  • Social Support
  • Psychiatry
  • Prospective Studies
  • Middle Aged
  • Male
  • Life Change Events
  • Immunity, Cellular
  • Hydrocortisone
  • Humans