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The role of microparticles in the pathogenesis of rheumatic diseases.

Publication ,  Journal Article
Beyer, C; Pisetsky, DS
Published in: Nat Rev Rheumatol
January 2010

Microparticles (MPs) are small membrane-bound vesicles that are emerging as important elements in the pathogenesis of rheumatic diseases owing to their pleiotropic effects on thrombosis, vascular reactivity, angiogenesis and inflammation. Released from cells during activation and apoptosis, MPs carry proteins, lipids and nucleic acids, and serve as platforms for enzymatic processes in thrombosis. Furthermore, MPs can transfer cytokines, receptors, RNA and DNA to modulate the properties of target cells. As MPs appear in the blood in increased numbers during rheumatic disease, they represent novel biomarkers that can be used to assess events in otherwise inaccessible tissues. Future research will define further the pathogenetic role of MPs and explore therapeutic strategies to block their release or signaling properties.

Duke Scholars

Published In

Nat Rev Rheumatol

DOI

EISSN

1759-4804

Publication Date

January 2010

Volume

6

Issue

1

Start / End Page

21 / 29

Location

United States

Related Subject Headings

  • Rheumatic Diseases
  • Humans
  • Cell-Derived Microparticles
  • Biomarkers
  • Animals
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Beyer, C., & Pisetsky, D. S. (2010). The role of microparticles in the pathogenesis of rheumatic diseases. Nat Rev Rheumatol, 6(1), 21–29. https://doi.org/10.1038/nrrheum.2009.229
Beyer, Christian, and David S. Pisetsky. “The role of microparticles in the pathogenesis of rheumatic diseases.Nat Rev Rheumatol 6, no. 1 (January 2010): 21–29. https://doi.org/10.1038/nrrheum.2009.229.
Beyer C, Pisetsky DS. The role of microparticles in the pathogenesis of rheumatic diseases. Nat Rev Rheumatol. 2010 Jan;6(1):21–9.
Beyer, Christian, and David S. Pisetsky. “The role of microparticles in the pathogenesis of rheumatic diseases.Nat Rev Rheumatol, vol. 6, no. 1, Jan. 2010, pp. 21–29. Pubmed, doi:10.1038/nrrheum.2009.229.
Beyer C, Pisetsky DS. The role of microparticles in the pathogenesis of rheumatic diseases. Nat Rev Rheumatol. 2010 Jan;6(1):21–29.

Published In

Nat Rev Rheumatol

DOI

EISSN

1759-4804

Publication Date

January 2010

Volume

6

Issue

1

Start / End Page

21 / 29

Location

United States

Related Subject Headings

  • Rheumatic Diseases
  • Humans
  • Cell-Derived Microparticles
  • Biomarkers
  • Animals
  • 3202 Clinical sciences
  • 1103 Clinical Sciences