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Ir genes of different high responder haplotypes for staphylococcal nuclease are not allelic.

Publication ,  Journal Article
Berzofsky, JA; Pisetsky, DS; Killion, DJ; Hicks, G; Sachs, DH
Published in: J Immunol
December 1981

The Ir gene controlling high responsiveness to staphylococcal nuclease in the H-2d haplotype has been mapped to the I-A subregion, in contrast to that in the H-2k and H-2a haplotypes, which maps in the I-B subregion. The nonallelic high responder genes also confer differences in fine specificity on the antibodies produced. This nonallelism of Ir genes for the same antigen in different haplotypes is consistent with Ir gene mechanisms involving associative recognition of antigen plus Ia by T lymphocytes. It further suggests that products of different subregions can perform the same function.

Duke Scholars

Published In

J Immunol

ISSN

0022-1767

Publication Date

December 1981

Volume

127

Issue

6

Start / End Page

2453 / 2455

Location

United States

Related Subject Headings

  • Micrococcal Nuclease
  • Mice, Inbred DBA
  • Mice, Inbred C57BL
  • Mice
  • Immunology
  • Haploidy
  • H-2 Antigens
  • Genes, MHC Class II
  • Dose-Response Relationship, Immunologic
  • Antibody Specificity
 

Citation

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Berzofsky, J. A., Pisetsky, D. S., Killion, D. J., Hicks, G., & Sachs, D. H. (1981). Ir genes of different high responder haplotypes for staphylococcal nuclease are not allelic. J Immunol, 127(6), 2453–2455.
Berzofsky, J. A., D. S. Pisetsky, D. J. Killion, G. Hicks, and D. H. Sachs. “Ir genes of different high responder haplotypes for staphylococcal nuclease are not allelic.J Immunol 127, no. 6 (December 1981): 2453–55.
Berzofsky JA, Pisetsky DS, Killion DJ, Hicks G, Sachs DH. Ir genes of different high responder haplotypes for staphylococcal nuclease are not allelic. J Immunol. 1981 Dec;127(6):2453–5.
Berzofsky, J. A., et al. “Ir genes of different high responder haplotypes for staphylococcal nuclease are not allelic.J Immunol, vol. 127, no. 6, Dec. 1981, pp. 2453–55.
Berzofsky JA, Pisetsky DS, Killion DJ, Hicks G, Sachs DH. Ir genes of different high responder haplotypes for staphylococcal nuclease are not allelic. J Immunol. 1981 Dec;127(6):2453–2455.

Published In

J Immunol

ISSN

0022-1767

Publication Date

December 1981

Volume

127

Issue

6

Start / End Page

2453 / 2455

Location

United States

Related Subject Headings

  • Micrococcal Nuclease
  • Mice, Inbred DBA
  • Mice, Inbred C57BL
  • Mice
  • Immunology
  • Haploidy
  • H-2 Antigens
  • Genes, MHC Class II
  • Dose-Response Relationship, Immunologic
  • Antibody Specificity