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Functional alterations of macrophages in autoimmune MRL-lpr/lpr mice.

Publication ,  Journal Article
Dang-Vu, AP; Pisetsky, DS; Weinberg, JB
Published in: J Immunol
March 15, 1987

To assess the role of macrophages (MAC) in the pathogenesis of systemic lupus erythematosus, we investigated functional aspects of peritoneal MAC obtained from autoimmune MRL/MpJ-lpr/lpr (MRL-lpr) mice. MRL-lpr and control C3H/HeN MAC were obtained from untreated mice or mice injected i.p. with 1 ml of 10% sterile peptone 3 days before cell harvest. MRL-lpr mice had significantly more peritoneal cells (MAC and lymphocytes) than did control mice. In endotoxin-free conditions, MRL-lpr MAC were similar to C3H/HeN MAC in their baseline, and IFN-gamma and/or LPS enhanced cytolysis of 3T12 fibrosarcoma tumor cells. Compared with C3H/HeN MAC, MRL-lpr MAC had a significant increase in antibody-dependent cellular cytotoxicity activity against sheep erythrocytes. This enhanced activity was not accompanied by a similar increase in adherence and/or phagocytosis of the same targets. Finally, in response to phorbol myristate acetate stimulation, both resident and peptone-induced MAC from MRL-lpr mice produced significantly more hydrogen peroxide than did those from control mice. These results indicate that MAC from MRL-lpr mice display features of selective "activation", and suggest that MAC or their products may play a role in the pathogenesis of inflammatory disorders seen in autoimmune diseases.

Duke Scholars

Published In

J Immunol

ISSN

0022-1767

Publication Date

March 15, 1987

Volume

138

Issue

6

Start / End Page

1757 / 1761

Location

United States

Related Subject Headings

  • Phagocytosis
  • Peritoneal Cavity
  • Mice, Mutant Strains
  • Mice
  • Macrophages
  • Macrophage Activation
  • Lupus Erythematosus, Systemic
  • Lipopolysaccharides
  • Interferon-gamma
  • Immunology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Dang-Vu, A. P., Pisetsky, D. S., & Weinberg, J. B. (1987). Functional alterations of macrophages in autoimmune MRL-lpr/lpr mice. J Immunol, 138(6), 1757–1761.
Dang-Vu, A. P., D. S. Pisetsky, and J. B. Weinberg. “Functional alterations of macrophages in autoimmune MRL-lpr/lpr mice.J Immunol 138, no. 6 (March 15, 1987): 1757–61.
Dang-Vu AP, Pisetsky DS, Weinberg JB. Functional alterations of macrophages in autoimmune MRL-lpr/lpr mice. J Immunol. 1987 Mar 15;138(6):1757–61.
Dang-Vu, A. P., et al. “Functional alterations of macrophages in autoimmune MRL-lpr/lpr mice.J Immunol, vol. 138, no. 6, Mar. 1987, pp. 1757–61.
Dang-Vu AP, Pisetsky DS, Weinberg JB. Functional alterations of macrophages in autoimmune MRL-lpr/lpr mice. J Immunol. 1987 Mar 15;138(6):1757–1761.

Published In

J Immunol

ISSN

0022-1767

Publication Date

March 15, 1987

Volume

138

Issue

6

Start / End Page

1757 / 1761

Location

United States

Related Subject Headings

  • Phagocytosis
  • Peritoneal Cavity
  • Mice, Mutant Strains
  • Mice
  • Macrophages
  • Macrophage Activation
  • Lupus Erythematosus, Systemic
  • Lipopolysaccharides
  • Interferon-gamma
  • Immunology