Mechanisms of antinuclear antibody production in the rheumatic diseases.
Publication
, Journal Article
Pisetsky, DS
Published in: Rheum Dis Clin North Am
December 1987
Recent investigations on the mechanisms of ANA production in the rheumatic diseases suggest that these responses frequently emerge in the setting of nonspecific immunoregulatory disturbances. However, the expansion and maturation of these responses to generate pathogenic specificities may require the coexistence of clonal or antigen-specific abnormalities. At the genetic level, ANAs appear to be of diverse origin, including some with representation in the normal B cell repertoire. Since some ANAs are disease-specific, elucidation of the basis of their production should provide insights into the unique pathogenetic features of different rheumatic diseases.
Duke Scholars
Published In
Rheum Dis Clin North Am
ISSN
0889-857X
Publication Date
December 1987
Volume
13
Issue
3
Start / End Page
569 / 581
Location
United States
Related Subject Headings
- Mice
- Lupus Erythematosus, Systemic
- Humans
- Autoantigens
- Autoantibodies
- Arthritis & Rheumatology
- Antibodies, Antinuclear
- Animals
- 3202 Clinical sciences
- 1103 Clinical Sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Pisetsky, D. S. (1987). Mechanisms of antinuclear antibody production in the rheumatic diseases. Rheum Dis Clin North Am, 13(3), 569–581.
Pisetsky, D. S. “Mechanisms of antinuclear antibody production in the rheumatic diseases.” Rheum Dis Clin North Am 13, no. 3 (December 1987): 569–81.
Pisetsky DS. Mechanisms of antinuclear antibody production in the rheumatic diseases. Rheum Dis Clin North Am. 1987 Dec;13(3):569–81.
Pisetsky, D. S. “Mechanisms of antinuclear antibody production in the rheumatic diseases.” Rheum Dis Clin North Am, vol. 13, no. 3, Dec. 1987, pp. 569–81.
Pisetsky DS. Mechanisms of antinuclear antibody production in the rheumatic diseases. Rheum Dis Clin North Am. 1987 Dec;13(3):569–581.
Published In
Rheum Dis Clin North Am
ISSN
0889-857X
Publication Date
December 1987
Volume
13
Issue
3
Start / End Page
569 / 581
Location
United States
Related Subject Headings
- Mice
- Lupus Erythematosus, Systemic
- Humans
- Autoantigens
- Autoantibodies
- Arthritis & Rheumatology
- Antibodies, Antinuclear
- Animals
- 3202 Clinical sciences
- 1103 Clinical Sciences