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Enhancing immunogenicity by CpG DNA.

Publication ,  Journal Article
Jiang, W; Pisetsky, DS
Published in: Curr Opin Mol Ther
April 2003

Bacterial DNA and oligonucleotides containing unmethylated CpG dinucleotides (CpG DNA) can stimulate immune responses and have potential for use as novel agents to enhance immunogenicity. CpG DNA can interact with toll-like receptor 9 and cause activation through a myeloid differentiation primary response gene (MyD88)-dependent signaling pathway. Due to its pattern of immune cell activation, CpG DNA can induce a cytokine milieu to promote T-helper cell responses and serve as an adjuvant. Furthermore, CpG DNA can provide protection against pathogens in animal models and has therapeutic applications in clinical settings such as in cancer and allergy.

Duke Scholars

Published In

Curr Opin Mol Ther

ISSN

1464-8431

Publication Date

April 2003

Volume

5

Issue

2

Start / End Page

180 / 185

Location

England

Related Subject Headings

  • Toll-Like Receptor 9
  • Receptors, Cell Surface
  • Oligonucleotides
  • Immunity
  • Humans
  • DNA-Binding Proteins
  • Biotechnology
  • Animals
  • Adjuvants, Immunologic
  • 3206 Medical biotechnology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Jiang, W., & Pisetsky, D. S. (2003). Enhancing immunogenicity by CpG DNA. Curr Opin Mol Ther, 5(2), 180–185.
Jiang, Weiwen, and David S. Pisetsky. “Enhancing immunogenicity by CpG DNA.Curr Opin Mol Ther 5, no. 2 (April 2003): 180–85.
Jiang W, Pisetsky DS. Enhancing immunogenicity by CpG DNA. Curr Opin Mol Ther. 2003 Apr;5(2):180–5.
Jiang, Weiwen, and David S. Pisetsky. “Enhancing immunogenicity by CpG DNA.Curr Opin Mol Ther, vol. 5, no. 2, Apr. 2003, pp. 180–85.
Jiang W, Pisetsky DS. Enhancing immunogenicity by CpG DNA. Curr Opin Mol Ther. 2003 Apr;5(2):180–185.

Published In

Curr Opin Mol Ther

ISSN

1464-8431

Publication Date

April 2003

Volume

5

Issue

2

Start / End Page

180 / 185

Location

England

Related Subject Headings

  • Toll-Like Receptor 9
  • Receptors, Cell Surface
  • Oligonucleotides
  • Immunity
  • Humans
  • DNA-Binding Proteins
  • Biotechnology
  • Animals
  • Adjuvants, Immunologic
  • 3206 Medical biotechnology