Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel

Serum immunoglobulin levels in systemic lupus erythematosus: the effects of age, sex, race and disease duration.

Publication ,  Journal Article
Ward, MM; Dawson, DV; Pisetsky, DS
Published in: J Rheumatol
April 1991

To determine whether factors other than disease activity influence immunoglobulin levels in patients with systemic lupus erythematosus (SLE), the effect of age, sex, race, and duration of disease on serum IgG and IgM levels in 170 patients with SLE were investigated. Serum IgM and IgG levels did not differ between men and women, while IgM levels were higher in whites. Serum IgG levels did not vary with age or duration of SLE. In contrast, serum IgM levels were negatively correlated with both age (r = -0.236; p = 0.002) and duration of SLE (r = 0.248; p = 0.001), and demonstrated a U-shaped age relationship, being higher in children and older patients. These patterns of immunoglobulin expression in patients with SLE contrast with those exhibited in populations of healthy individuals, suggesting that the immunoregulatory disturbances of SLE predominate over the normal mechanisms regulating levels of IgM and IgG.

Duke Scholars

Published In

J Rheumatol

ISSN

0315-162X

Publication Date

April 1991

Volume

18

Issue

4

Start / End Page

540 / 544

Location

Canada

Related Subject Headings

  • White People
  • Time Factors
  • Osmolar Concentration
  • Middle Aged
  • Male
  • Lupus Erythematosus, Systemic
  • Immunoglobulins
  • Humans
  • Female
  • DNA
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Ward, M. M., Dawson, D. V., & Pisetsky, D. S. (1991). Serum immunoglobulin levels in systemic lupus erythematosus: the effects of age, sex, race and disease duration. J Rheumatol, 18(4), 540–544.
Ward, M. M., D. V. Dawson, and D. S. Pisetsky. “Serum immunoglobulin levels in systemic lupus erythematosus: the effects of age, sex, race and disease duration.J Rheumatol 18, no. 4 (April 1991): 540–44.
Ward, M. M., et al. “Serum immunoglobulin levels in systemic lupus erythematosus: the effects of age, sex, race and disease duration.J Rheumatol, vol. 18, no. 4, Apr. 1991, pp. 540–44.

Published In

J Rheumatol

ISSN

0315-162X

Publication Date

April 1991

Volume

18

Issue

4

Start / End Page

540 / 544

Location

Canada

Related Subject Headings

  • White People
  • Time Factors
  • Osmolar Concentration
  • Middle Aged
  • Male
  • Lupus Erythematosus, Systemic
  • Immunoglobulins
  • Humans
  • Female
  • DNA