Role of Toll-like receptors in HMGB1 release from macrophages.
Publication
, Journal Article
Pisetsky, DS; Jiang, W
Published in: Ann N Y Acad Sci
August 2007
HMGB1 is a nonhistone nuclear protein that can serve as a cytokine and activate innate immunity. The translocation of this molecule from the inside to the outside of cells is a critical event in inflammation, occurring following activation of certain Toll-like receptors (TLRs) as well as during the course of apoptotic as well as necrotic cell death. Because the kinetics of HMGB1 release differs from that of a conventional cytokine, it provides a broader therapeutic window and may be an important new target of therapy for inflammatory, autoimmune, and infectious diseases.
Duke Scholars
Published In
Ann N Y Acad Sci
DOI
ISSN
0077-8923
Publication Date
August 2007
Volume
1109
Start / End Page
58 / 65
Location
United States
Related Subject Headings
- Toll-Like Receptors
- Models, Immunological
- Macrophages
- Lymphocyte Activation
- Ligands
- Humans
- HMGB1 Protein
- General Science & Technology
- Cell Death
- Animals
Citation
APA
Chicago
ICMJE
MLA
NLM
Pisetsky, D. S., & Jiang, W. (2007). Role of Toll-like receptors in HMGB1 release from macrophages. Ann N Y Acad Sci, 1109, 58–65. https://doi.org/10.1196/annals.1398.008
Pisetsky, David S., and Weiwen Jiang. “Role of Toll-like receptors in HMGB1 release from macrophages.” Ann N Y Acad Sci 1109 (August 2007): 58–65. https://doi.org/10.1196/annals.1398.008.
Pisetsky DS, Jiang W. Role of Toll-like receptors in HMGB1 release from macrophages. Ann N Y Acad Sci. 2007 Aug;1109:58–65.
Pisetsky, David S., and Weiwen Jiang. “Role of Toll-like receptors in HMGB1 release from macrophages.” Ann N Y Acad Sci, vol. 1109, Aug. 2007, pp. 58–65. Pubmed, doi:10.1196/annals.1398.008.
Pisetsky DS, Jiang W. Role of Toll-like receptors in HMGB1 release from macrophages. Ann N Y Acad Sci. 2007 Aug;1109:58–65.
Published In
Ann N Y Acad Sci
DOI
ISSN
0077-8923
Publication Date
August 2007
Volume
1109
Start / End Page
58 / 65
Location
United States
Related Subject Headings
- Toll-Like Receptors
- Models, Immunological
- Macrophages
- Lymphocyte Activation
- Ligands
- Humans
- HMGB1 Protein
- General Science & Technology
- Cell Death
- Animals