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Structure and function of anti-DNA autoantibodies derived from a single autoimmune mouse.

Publication ,  Journal Article
Shlomchik, MJ; Aucoin, AH; Pisetsky, DS; Weigert, MG
Published in: Proc Natl Acad Sci U S A
December 1987

Four monoclonal anti-DNA antibodies derived from a single autoimmune MRL/lpr mouse were studied. Three of these antibodies showed similarities in DNA binding; the fourth had a much higher specific activity for single-stranded DNA and, in addition, was unique in binding double-stranded DNA and cardiolipin. Complete nucleotide sequences of heavy- and light-chain variable regions demonstrated that all four antibodies are clonally related. The sequences also showed numerous somatic mutations, the distribution of which suggests that positive selection by antigen operated on these clonally related autoantibodies.

Duke Scholars

Published In

Proc Natl Acad Sci U S A

DOI

ISSN

0027-8424

Publication Date

December 1987

Volume

84

Issue

24

Start / End Page

9150 / 9154

Location

United States

Related Subject Headings

  • Mutation
  • Molecular Sequence Data
  • Mice, Mutant Strains
  • Mice
  • Lupus Erythematosus, Systemic
  • Immunoglobulin Variable Region
  • Genes, Immunoglobulin
  • DNA
  • Cardiolipins
  • Base Sequence
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Shlomchik, M. J., Aucoin, A. H., Pisetsky, D. S., & Weigert, M. G. (1987). Structure and function of anti-DNA autoantibodies derived from a single autoimmune mouse. Proc Natl Acad Sci U S A, 84(24), 9150–9154. https://doi.org/10.1073/pnas.84.24.9150
Shlomchik, M. J., A. H. Aucoin, D. S. Pisetsky, and M. G. Weigert. “Structure and function of anti-DNA autoantibodies derived from a single autoimmune mouse.Proc Natl Acad Sci U S A 84, no. 24 (December 1987): 9150–54. https://doi.org/10.1073/pnas.84.24.9150.
Shlomchik MJ, Aucoin AH, Pisetsky DS, Weigert MG. Structure and function of anti-DNA autoantibodies derived from a single autoimmune mouse. Proc Natl Acad Sci U S A. 1987 Dec;84(24):9150–4.
Shlomchik, M. J., et al. “Structure and function of anti-DNA autoantibodies derived from a single autoimmune mouse.Proc Natl Acad Sci U S A, vol. 84, no. 24, Dec. 1987, pp. 9150–54. Pubmed, doi:10.1073/pnas.84.24.9150.
Shlomchik MJ, Aucoin AH, Pisetsky DS, Weigert MG. Structure and function of anti-DNA autoantibodies derived from a single autoimmune mouse. Proc Natl Acad Sci U S A. 1987 Dec;84(24):9150–9154.
Journal cover image

Published In

Proc Natl Acad Sci U S A

DOI

ISSN

0027-8424

Publication Date

December 1987

Volume

84

Issue

24

Start / End Page

9150 / 9154

Location

United States

Related Subject Headings

  • Mutation
  • Molecular Sequence Data
  • Mice, Mutant Strains
  • Mice
  • Lupus Erythematosus, Systemic
  • Immunoglobulin Variable Region
  • Genes, Immunoglobulin
  • DNA
  • Cardiolipins
  • Base Sequence